Inhca inhibitor of carbonic anhydrase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Inhcaprovided by RGD
Official Full Name: inhibitor of carbonic anhydraseprovided by RGD
Primary source: RGD:1310507
See related: EnsemblRapid:ENSRNOG00000009434 AllianceGenome:RGD:1310507
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Aa2-001; LRRGT00077; LRRGT00161; RGD1310507
Summary: Predicted to enable enzyme inhibitor activity. Predicted to be involved in antibacterial humoral response and iron ion transport. Predicted to be active in endosome; extracellular space; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 5483.1) See more
Orthologs: mouse all
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Genomic context

Location:: 8q32

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (112715733..112753950, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (103836846..103874980, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (111742987..111762747, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme inhibitor activity	ISO Inferred from Sequence Orthology more info
NOT enables iron ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron ion transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Inhibitor of carbonic anhydrase; inhibitor of carbonic anhydrase

Names: Inhibitor of carbonic anhydrase-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001047891.2 → NP_001041356.2 Inhibitor of carbonic anhydrase precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I6AEF9, A0A8I6AHP0

Related

ENSRNOP00000074521.3, ENSRNOT00000083855.3

Conserved Domains (2) summary

cd13617
Location:352 → 684

PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily

cd13618
Location:24 → 346

PBP2_transferrin_N; The N-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

112715733..112753950 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063265605.1 → XP_063121675.1 inhibitor of carbonic anhydrase isoform X3
XM_039081555.2 → XP_038937483.1 inhibitor of carbonic anhydrase isoform X1

UniProtKB/TrEMBL

A0A0G2K896, A0A8I6AHP0

Related

ENSRNOP00000090502.2, ENSRNOT00000108282.2

Conserved Domains (2) summary

cd13617
Location:367 → 699

PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily

cd13618
Location:39 → 361

PBP2_transferrin_N; The N-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
XM_039081556.2 → XP_038937484.1 inhibitor of carbonic anhydrase isoform X2

UniProtKB/TrEMBL

A0A8I6AHP0

Conserved Domains (2) summary

cd13617
Location:353 → 685

PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily

cd13618
Location:39 → 347

PBP2_transferrin_N; The N-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily