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Mapkapk3 MAPK activated protein kinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315994, updated on 2-Nov-2024

Summary

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Official Symbol
Mapkapk3provided by RGD
Official Full Name
MAPK activated protein kinase 3provided by RGD
Primary source
RGD:1304980
See related
EnsemblRapid:ENSRNOG00000014832 AllianceGenome:RGD:1304980
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MK-3; MAPKAP-K3
Summary
Predicted to enable calmodulin binding activity; mitogen-activated protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including macropinocytosis; peptidyl-serine phosphorylation; and response to lipopolysaccharide. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in patterned macular dystrophy 3. Orthologous to human MAPKAPK3 (MAPK activated protein kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 184.3), Heart (RPKM 103.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mapkapk3 in Genome Data Viewer
Location:
8q32
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (116808429..116842228, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (107929754..107963638, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116012126..116046012, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene dedicator of cyto-kinesis 3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene bleomycin hydrolase, pseudogene 1 Neighboring gene ribosomal protein SA, pseudogene 9 Neighboring gene cytokine inducible SH2-containing protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27. Lavoie JN, et al. Mol Cell Biol, 1995 Jan. PMID 7799959, Free PMC Article
  2. A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. Clifton AD, et al. FEBS Lett, 1996 Sep 2. PMID 8774846
  3. The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Zaru R, et al. Nat Immunol, 2007 Nov. PMID 17906627
  4. MAPKAP kinases - MKs - two's company, three's a crowd. Gaestel M. Nat Rev Mol Cell Biol, 2006 Feb. PMID 16421520
  5. The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. Eyers CE, et al. Biochem J, 2005 Jul 1. PMID 15850461, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium/calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in macropinocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in macropinocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to cytokine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to cytokine ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cytokine ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MAP kinase-activated protein kinase 3
Names
MAPKAP kinase 3
MAPKAPK-3
mitogen-activated protein kinase-activated protein kinase 3
NP_001012127.1
XP_008764753.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012127.1 → NP_001012127.1  MAP kinase-activated protein kinase 3

    See identical proteins and their annotated locations for NP_001012127.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081974
    UniProtKB/Swiss-Prot
    Q66H84
    UniProtKB/TrEMBL
    A0A8I6AVR4, A6I2W4
    Related
    ENSRNOP00000020065.3, ENSRNOT00000020065.7
    Conserved Domains (1) summary
    cd14172
    Location:41 → 306
    STKc_MAPKAPK3; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    116808429..116842228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766531.4 → XP_008764753.1  MAP kinase-activated protein kinase 3 isoform X1

    See identical proteins and their annotated locations for XP_008764753.1

    UniProtKB/Swiss-Prot
    Q66H84
    UniProtKB/TrEMBL
    A0A8I6AVR4, A6I2W4
    Conserved Domains (1) summary
    cd14172
    Location:41 → 306
    STKc_MAPKAPK3; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66H84.1 GenPept UniProtKB/Swiss-Prot:Q66H84

Gene LinkOut

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