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Arih2 ariadne RBR E3 ubiquitin protein ligase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316005, updated on 2-Nov-2024

Summary

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Official Symbol
Arih2provided by RGD
Official Full Name
ariadne RBR E3 ubiquitin protein ligase 2provided by RGD
Primary source
RGD:1305839
See related
EnsemblRapid:ENSRNOG00000031827 AllianceGenome:RGD:1305839
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ARI2; TRIAD1
Summary
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including hematopoietic stem cell proliferation; positive regulation of protein targeting to mitochondrion; and protein polyubiquitination. Predicted to be located in nucleoplasm. Predicted to be part of Cul5-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 181.6), Heart (RPKM 148.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arih2 in Genome Data Viewer
Location:
8q32
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118175267..118234425, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109296738..109355909, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117387004..117446085, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene DALR anticodon binding domain containing 3 Neighboring gene WD repeat domain 6 Neighboring gene prolyl 4-hydroxylase, transmembrane Neighboring gene uncharacterized LOC120094262 Neighboring gene solute carrier family 25 member 20 Neighboring gene uncharacterized LOC134480235 Neighboring gene protein kinase cAMP-dependent type II regulatory subunit alpha Neighboring gene uncharacterized LOC134480236

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ubiquitin ligase Triad1 promotes neurite outgrowth by inhibiting MDM2-mediated ubiquitination of the neuroprotective factor pleiotrophin. Wu C, et al. J Biol Chem, 2022 Oct. PMID 36055408, Free PMC Article
  2. E3 ubiquitin ligase Triad1 promotes neuronal apoptosis by regulating the p53-caspase3 pathway after spinal cord injury. Wu C, et al. Somatosens Mot Res, 2022 Mar. PMID 34641746
  3. The expression of TRIAD1 and DISC1 after traumatic brain injury and its influence on NSCs. Jiang R, et al. Stem Cell Res Ther, 2018 Nov 8. PMID 30409224, Free PMC Article
  4. Triad1 regulates the expression and distribution of EHD1 contributing to the neurite outgrowth of neurons after spinal cord injury. Wu C, et al. J Cell Biochem, 2019 Apr. PMID 30320922
  5. The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells. Marteijn JA, et al. Blood, 2005 Dec 15. PMID 16118314

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubiquitin ligase Triad1 promotes neurite outgrowth by inhibiting MDM2-mediated ubiquitination of the neuroprotective factor pleiotrophin.
    Title: Ubiquitin ligase Triad1 promotes neurite outgrowth by inhibiting MDM2-mediated ubiquitination of the neuroprotective factor pleiotrophin.
  2. E3 ubiquitin ligase Triad1 promotes neuronal apoptosis by regulating the p53-caspase3 pathway after spinal cord injury.
    Title: E3 ubiquitin ligase Triad1 promotes neuronal apoptosis by regulating the p53-caspase3 pathway after spinal cord injury.
  3. Our data delineate a novel interaction between Triad1 and EHD1 that may contribute to the regulation of neurite outgrowth for neurons after the spinal cord injury.
    Title: Triad1 regulates the expression and distribution of EHD1 contributing to the neurite outgrowth of neurons after spinal cord injury.
  4. the expression of TRIAD1 and DISC1 change after traumatic brain injury and that their interaction may affect the proliferation and differentiation of neural stem cells.
    Title: The expression of TRIAD1 and DISC1 after traumatic brain injury and its influence on NSCs.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in hematopoietic stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul5-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase ARIH2
Names
ariadne homolog 2
NP_001012275.1
XP_006243847.1
XP_006243849.1
XP_008764759.1
XP_038937528.1
XP_063121700.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012275.2 → NP_001012275.1  E3 ubiquitin-protein ligase ARIH2

    See identical proteins and their annotated locations for NP_001012275.1

    Status: VALIDATED

    Source sequence(s)
    BF284740, CB702620, CV114328, CV126331, JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6A0Y1, A6I373, D3ZJB8
    Related
    ENSRNOP00000050012.3, ENSRNOT00000042577.6
    Conserved Domains (3) summary
    smart00647
    Location:207 → 269
    IBR; In Between Ring fingers
    cd16773
    Location:136 → 189
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:297 → 329
    IBR; IBR domain, a half RING-finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    118175267..118234425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766537.4 → XP_008764759.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

    See identical proteins and their annotated locations for XP_008764759.1

    UniProtKB/TrEMBL
    A0A8I6A0Y1, A6I373, D3ZJB8
    Conserved Domains (3) summary
    smart00647
    Location:207 → 269
    IBR; In Between Ring fingers
    cd16773
    Location:136 → 189
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:297 → 329
    IBR; IBR domain, a half RING-finger domain

  2. XM_006243785.5 → XP_006243847.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

    See identical proteins and their annotated locations for XP_006243847.1

    UniProtKB/TrEMBL
    A0A8I6A0Y1, A6I373, D3ZJB8
    Conserved Domains (3) summary
    smart00647
    Location:207 → 269
    IBR; In Between Ring fingers
    cd16773
    Location:136 → 189
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:297 → 329
    IBR; IBR domain, a half RING-finger domain

  3. XM_039081600.2 → XP_038937528.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A0Y1, A6I373, D3ZJB8
    Conserved Domains (3) summary
    smart00647
    Location:207 → 269
    IBR; In Between Ring fingers
    cd16773
    Location:136 → 189
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:297 → 329
    IBR; IBR domain, a half RING-finger domain

  4. XM_006243787.4 → XP_006243849.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A0Y1
    Conserved Domains (2) summary
    smart00647
    Location:136 → 198
    IBR; In Between Ring fingers
    pfam01485
    Location:226 → 258
    IBR; IBR domain, a half RING-finger domain

  5. XM_063265630.1 → XP_063121700.1  E3 ubiquitin-protein ligase ARIH2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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