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Ccdc51 coiled-coil domain containing 51 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316008, updated on 2-Nov-2024

Summary

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Official Symbol
Ccdc51provided by RGD
Official Full Name
coiled-coil domain containing 51provided by RGD
Primary source
RGD:1311466
See related
EnsemblRapid:ENSRNOG00000020688 AllianceGenome:RGD:1311466
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MITOK; RGD1311466
Summary
Predicted to enable mitochondrial ATP-gated potassium channel activity. Predicted to be involved in cell volume homeostasis and mitochondrial potassium ion transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial ATP-gated potassium channel complex. Orthologous to human CCDC51 (coiled-coil domain containing 51). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 46.1), Adrenal (RPKM 38.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ccdc51 in Genome Data Viewer
Location:
8q32
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118601002..118619943)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109722595..109741478)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117812091..117830848)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene three prime repair exonuclease 1 Neighboring gene ATR interacting protein Neighboring gene U2 spliceosomal RNA Neighboring gene translation machinery associated 7 homolog Neighboring gene plexin B1 Neighboring gene cytochrome c oxidase subunit 6C, pseudogene 2 Neighboring gene F-box and WD repeat domain containing 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of an ATP-sensitive potassium channel in mitochondria. Paggio A, et al. Nature, 2019 Aug. PMID 31435016, Free PMC Article
  2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mitochondrial ATP-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables mitochondrial ATP-gated potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cell volume homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial ATP-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial ATP-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial potassium channel
Names
coiled-coil domain-containing protein 51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014098.2 → NP_001014120.2  mitochondrial potassium channel

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q5PPN7
    UniProtKB/TrEMBL
    A0A8I6GKL1, A6I3B5
    Related
    ENSRNOP00000090082.2, ENSRNOT00000104394.2
    Conserved Domains (1) summary
    TIGR02169
    Location:112 → 264
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    118601002..118619943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243790.5 → XP_006243852.1  mitochondrial potassium channel isoform X2

    UniProtKB/TrEMBL
    A0A0G2JXH2, A0A0H2UHS3
    Conserved Domains (1) summary
    TIGR02169
    Location:131 → 283
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. XM_006243791.4 → XP_006243853.1  mitochondrial potassium channel isoform X3

    See identical proteins and their annotated locations for XP_006243853.1

    UniProtKB/Swiss-Prot
    Q5PPN7
    UniProtKB/TrEMBL
    A0A8I6GKL1, A6I3B5
    Related
    ENSRNOP00000070269.2, ENSRNOT00000077228.3
    Conserved Domains (1) summary
    TIGR02169
    Location:112 → 264
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  3. XM_006243789.5 → XP_006243851.1  mitochondrial potassium channel isoform X1

    UniProtKB/TrEMBL
    A0A8I6GKL1
    Related
    ENSRNOP00000094126.2, ENSRNOT00000102638.2
    Conserved Domains (1) summary
    TIGR02169
    Location:143 → 295
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  4. XM_006243792.5 → XP_006243854.1  mitochondrial potassium channel isoform X3

    See identical proteins and their annotated locations for XP_006243854.1

    UniProtKB/Swiss-Prot
    Q5PPN7
    UniProtKB/TrEMBL
    A0A8I6GKL1, A6I3B5
    Conserved Domains (1) summary
    TIGR02169
    Location:112 → 264
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PPN7.2 GenPept UniProtKB/Swiss-Prot:Q5PPN7

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