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Klhl18 kelch-like family member 18 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316012, updated on 18-Sep-2024

Summary

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Official Symbol
Klhl18provided by RGD
Official Full Name
kelch-like family member 18provided by RGD
Primary source
RGD:1310570
See related
EnsemblRapid:ENSRNOG00000020880 AllianceGenome:RGD:1310570
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310570
Summary
Predicted to be involved in positive regulation of mitotic cell cycle phase transition and protein ubiquitination. Orthologous to human KLHL18 (kelch like family member 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 64.2), Kidney (RPKM 51.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Klhl18 in Genome Data Viewer
Location:
8q32
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (119279081..119337850, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (110400679..110459442, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (118668809..118737672, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 23 Neighboring gene neutrophilic granule protein Neighboring gene kinesin family member 9 Neighboring gene SET domain containing 2, histone lysine methyltransferase Neighboring gene uncharacterized LOC108351781

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates Aurora-A. Moghe S, et al. Biol Open, 2012 Feb 15. PMID 23213400, Free PMC Article
  2. Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation. Chaya T, et al. EMBO J, 2019 Dec 2. PMID 31696965, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of mitotic cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kelch-like protein 18
Names
kelch-like 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399324.1 → NP_001386253.1  kelch-like protein 18 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    F1M3S0
    Related
    ENSRNOP00000052988.6, ENSRNOT00000056141.7
    Conserved Domains (4) summary
    PHA03098
    Location:34 → 552
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:326 → 369
    Kelch; KELCH repeat [structural motif]
    cd18247
    Location:19 → 134
    BTB_POZ_KLHL18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18)
    cd18457
    Location:135 → 241
    BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)

  2. NM_001399325.1 → NP_001386254.1  kelch-like protein 18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I5ZLS4
    Related
    ENSRNOP00000078958.1, ENSRNOT00000109992.2
    Conserved Domains (4) summary
    PHA03098
    Location:34 → 557
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:331 → 374
    Kelch; KELCH repeat [structural motif]
    cd18247
    Location:19 → 134
    BTB_POZ_KLHL18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18)
    cd18457
    Location:135 → 241
    BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    119279081..119337850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265631.1 → XP_063121701.1  kelch-like protein 18 isoform X1

  2. XM_006244007.4 → XP_006244069.1  kelch-like protein 18 isoform X1

    See identical proteins and their annotated locations for XP_006244069.1

    Conserved Domains (4) summary
    smart00612
    Location:277 → 323
    Kelch; Kelch domain
    sd00038
    Location:219 → 262
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:218 → 263
    Kelch_1; Kelch motif
    pfam07707
    Location:28 → 130
    BACK; BTB And C-terminal Kelch

  3. XM_039082647.2 → XP_038938575.1  kelch-like protein 18 isoform X3

    Conserved Domains (2) summary
    cd18247
    Location:19 → 134
    BTB_POZ_KLHL18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18)
    cd18457
    Location:135 → 241
    BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)

  4. XM_039082646.2 → XP_038938574.1  kelch-like protein 18 isoform X2

    Conserved Domains (5) summary
    smart00612
    Location:289 → 341
    Kelch; Kelch domain
    sd00038
    Location:282 → 327
    Kelch; KELCH repeat [structural motif]
    cd18247
    Location:19 → 134
    BTB_POZ_KLHL18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18)
    cd18457
    Location:135 → 241
    BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)
    pfam01344
    Location:330 → 375
    Kelch_1; Kelch motif

RNA

  1. XR_005488466.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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