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Oxsr1 oxidative stress responsive kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316064, updated on 17-Aug-2024

Summary

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Official Symbol
Oxsr1provided by RGD
Official Full Name
oxidative stress responsive kinase 1provided by RGD
Primary source
RGD:1310466
See related
EnsemblRapid:ENSRNOG00000013136 AllianceGenome:RGD:1310466
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including ATP binding activity; identical protein binding activity; and magnesium ion binding activity. Predicted to be involved in several processes, including cellular response to osmotic stress; chemokine-mediated signaling pathway; and protein phosphorylation. Predicted to be located in cytosol. Orthologous to human OXSR1 (oxidative stress responsive kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 210.8), Heart (RPKM 206.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q32
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (127850481..127941518, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (118972754..119062102, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (127920349..128009951, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 13-like Neighboring gene solute carrier family 22 member 13-like 1 Neighboring gene ribosomal protein lateral stalk subunit P0, pseudogene 7 Neighboring gene uncharacterized LOC120094290 Neighboring gene MYD88, innate immune signal transduction adaptor Neighboring gene acetyl-CoA acyltransferase 1A Neighboring gene xylulokinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MicroRNA-25-3p suppresses epileptiform discharges through inhibiting oxidative stress and apoptosis via targeting OXSR1 in neurons. Li R, et al. Biochem Biophys Res Commun, 2020 Mar 19. PMID 31954517
  2. MicroRNA-191-5p diminished sepsis-induced acute kidney injury through targeting oxidative stress responsive 1 in rat models. Qin Y, et al. Biosci Rep, 2019 Aug 30. PMID 31362998, Free PMC Article
  3. Taurine inhibits K+-Cl- cotransporter KCC2 to regulate embryonic Cl- homeostasis via with-no-lysine (WNK) protein kinase signaling pathway. Inoue K, et al. J Biol Chem, 2012 Jun 15. PMID 22544747, Free PMC Article
  4. WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells. Anselmo AN, et al. Proc Natl Acad Sci U S A, 2006 Jul 18. PMID 16832045, Free PMC Article
  5. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Vitari AC, et al. Biochem J, 2005 Oct 1. PMID 16083423, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.
    Title: Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.
  2. MicroRNA-25-3p suppresses epileptiform discharges through inhibiting oxidative stress and apoptosis via targeting OXSR1 in neurons.
    Title: MicroRNA-25-3p suppresses epileptiform discharges through inhibiting oxidative stress and apoptosis via targeting OXSR1 in neurons.
  3. MicroRNA-191-5p diminished sepsis-induced acute kidney injury through targeting oxidative stress responsive 1 in rat models.
    Title: MicroRNA-191-5p diminished sepsis-induced acute kidney injury through targeting oxidative stress responsive 1 in rat models.
  4. WNK1 and WNK4 both interacted with SPAK as well as a closely related kinase, termed oxidative stress response kinase-1.
    Title: The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell volume homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular hyperosmotic response ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular hypotonic response ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to chemokine ISO
Inferred from Sequence Orthology
more info
  
involved_in chemokine (C-C motif) ligand 21 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in chemokine (C-X-C motif) ligand 12 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of potassium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in osmosensory signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in renal sodium ion absorption ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase OSR1
Names
oxidative stress-responsive 1 protein
oxidative-stress responsive 1
NP_001101664.1
XP_063121724.1
XP_063121725.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108194.1 → NP_001101664.1  serine/threonine-protein kinase OSR1

    See identical proteins and their annotated locations for NP_001101664.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473954
    UniProtKB/Swiss-Prot
    A0A8I5ZNK2, A0A8I5ZZD5
    UniProtKB/TrEMBL
    A6I3V9, D3ZUC9
    Related
    ENSRNOP00000018056.5, ENSRNOT00000018056.7
    Conserved Domains (2) summary
    cd06610
    Location:15 → 291
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
    pfam12202
    Location:434 → 491
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    127850481..127941518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265654.1 → XP_063121724.1  serine/threonine-protein kinase OSR1 isoform X1

    UniProtKB/Swiss-Prot
    A0A8I5ZNK2, A0A8I5ZZD5

  2. XM_063265655.1 → XP_063121725.1  serine/threonine-protein kinase OSR1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A8I5ZNK2.1 GenPept UniProtKB/Swiss-Prot:A0A8I5ZNK2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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