Klhl40 kelch-like family member 40 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klhl40provided by RGD
Official Full Name: kelch-like family member 40provided by RGD
Primary source: RGD:1305368
See related: EnsemblRapid:ENSRNOG00000019390 AllianceGenome:RGD:1305368
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kbtbd5
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of protein metabolic process; and skeletal muscle fiber development. Predicted to act upstream of or within skeletal muscle fiber differentiation. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in A band and I band. Human ortholog(s) of this gene implicated in nemaline myopathy 8. Orthologous to human KLHL40 (kelch like family member 40). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 378.2), Adrenal (RPKM 53.3) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (130318793..130324309)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (121441285..121446801)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (130416265..130421871)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle fiber development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal muscle fiber development	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle fiber development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle fiber differentiation	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle fiber differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in A band	IBA Inferred from Biological aspect of Ancestor more info
located_in A band	ISO Inferred from Sequence Orthology more info
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
is_active_in I band	IBA Inferred from Biological aspect of Ancestor more info
located_in I band	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kelch-like protein 40

Names: kelch repeat and BTB (POZ) domain containing 5; kelch repeat and BTB domain-containing protein 5; kelch-like 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108195.2 → NP_001101665.2 kelch-like protein 40

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6I459, D4AA43

Related

ENSRNOP00000026234.6, ENSRNOT00000026234.7

Conserved Domains (3) summary

PHA03098
Location:47 → 594

PHA03098; kelch-like protein; Provisional

sd00038
Location:402 → 448

Kelch; KELCH repeat [structural motif]

cl38908
Location:6 → 137

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily