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Abcc10 ATP binding cassette subfamily C member 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316231, updated on 2-Nov-2024

Summary

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Official Symbol
Abcc10provided by RGD
Official Full Name
ATP binding cassette subfamily C member 10provided by RGD
Primary source
RGD:1306696
See related
EnsemblRapid:ENSRNOG00000018863 AllianceGenome:RGD:1306696
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ABC-type glutathione S-conjugate transporter activity and ABC-type xenobiotic transporter activity. Predicted to be involved in leukotriene metabolic process; leukotriene transport; and transmembrane transport. Predicted to be located in basolateral plasma membrane. Predicted to be active in membrane. Orthologous to human ABCC10 (ATP binding cassette subfamily C member 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 30.1), Kidney (RPKM 27.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Abcc10 in Genome Data Viewer
Location:
9q12
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (22154811..22174743)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14657242..14677178)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (17041351..17061263)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 318 Neighboring gene uncharacterized LOC120094785 Neighboring gene uncharacterized LOC134480556 Neighboring gene U6 spliceosomal RNA Neighboring gene delta like non-canonical Notch ligand 2 Neighboring gene tight junction associated protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transport of xenobiotics across the blood-brain barrier. Hagenbuch B, et al. News Physiol Sci, 2002 Dec. PMID 12433976
  2. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ABC-type glutathione S-conjugate transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ABC-type transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ABC-type xenobiotic transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in leukotriene metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in leukotriene transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP-binding cassette sub-family C member 10
Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ATP-binding cassette, subfamily C (CFTR/MRP), member 10
multidrug resistance-associated protein 7
NP_001101671.1
XP_038939448.1
XP_038939449.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108201.1 → NP_001101671.1  ATP-binding cassette sub-family C member 10

    See identical proteins and their annotated locations for NP_001101671.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473987
    UniProtKB/TrEMBL
    A6JIR4, D3ZX04
    Related
    ENSRNOP00000025598.6, ENSRNOT00000025598.9
    Conserved Domains (5) summary
    cd03244
    Location:1246 → 1465
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:599 → 802
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:211 → 1485
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:957 → 1190
    ABC_membrane; ABC transporter transmembrane region
    cl01709
    Location:1201 → 1274
    PBP2_NikA_DppA_OppA_like; The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    22154811..22174743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083521.2 → XP_038939449.1  ATP-binding cassette sub-family C member 10 isoform X2

    Conserved Domains (2) summary
    TIGR00957
    Location:201 → 910
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd18598
    Location:289 → 572
    ABC_6TM_MRP7_D1_like; Six-transmembrane helical domain 1 (TMD1) of multidrug resistance-associated protein 7, and similar proteins

  2. XM_039083520.2 → XP_038939448.1  ATP-binding cassette sub-family C member 10 isoform X1

    UniProtKB/TrEMBL
    D3ZX04
    Conserved Domains (1) summary
    TIGR00957
    Location:201 → 1323
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

RNA

  1. XR_005488894.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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