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Enpp5 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316249, updated on 2-Nov-2024

Summary

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Official Symbol
Enpp5provided by RGD
Official Full Name
ectonucleotide pyrophosphatase/phosphodiesterase family member 5provided by RGD
Primary source
RGD:1359199
See related
EnsemblRapid:ENSRNOG00000010232 AllianceGenome:RGD:1359199
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Npp5; E-NPP 5
Summary
Predicted to enable NAD+ diphosphatase activity and zinc ion binding activity. Involved in cell communication. Located in plasma membrane. Orthologous to human ENPP5 (ectonucleotide pyrophosphatase/phosphodiesterase family member 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 570.8), Kidney (RPKM 371.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Enpp5 in Genome Data Viewer
Location:
9q13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (24407574..24415029, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (16910187..16917633, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (19469276..19476684, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480346 Neighboring gene uncharacterized LOC102555783 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 4 Neighboring gene regulator of calcineurin 2 Neighboring gene uncharacterized LOC120094639 Neighboring gene cytochrome P450, family 39, subfamily a, polypeptide 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of nucleotide pyrophosphatase-5 as an oligomannosidic glycoprotein in rat brain. Ohe Y, et al. Biochem Biophys Res Commun, 2003 Sep 5. PMID 12927778
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NPP-5 is a neural oligomannosidic glycoprotein that may participate in neural cell communications.
    Title: Characterization of nucleotide pyrophosphatase-5 as an oligomannosidic glycoprotein in rat brain.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC105517

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD+ diphosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell communication IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ectonucleotide pyrophosphatase/phosphodiesterase family member 5
Names
E-NPP5
NPP-5
ectonucleotide pyrophosphatase/phosphodiesterase 5
NP_001012762.1
XP_006244669.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012744.1 → NP_001012762.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 precursor

    See identical proteins and their annotated locations for NP_001012762.1

    Status: PROVISIONAL

    Source sequence(s)
    BC090331
    UniProtKB/Swiss-Prot
    P84039, Q5EAN9
    UniProtKB/TrEMBL
    A6JJ21
    Related
    ENSRNOP00000013703.4, ENSRNOT00000013703.8
    Conserved Domains (2) summary
    pfam01663
    Location:30 → 342
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:28 → 382
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    24407574..24415029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244607.5 → XP_006244669.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform X1

    See identical proteins and their annotated locations for XP_006244669.1

    UniProtKB/Swiss-Prot
    P84039, Q5EAN9
    UniProtKB/TrEMBL
    A6JJ21
    Conserved Domains (2) summary
    pfam01663
    Location:30 → 342
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:28 → 382
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P84039.2 GenPept UniProtKB/Swiss-Prot:P84039

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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