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Opn5 opsin 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316259, updated on 2-Nov-2024

Summary

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Official Symbol
Opn5provided by RGD
Official Full Name
opsin 5provided by RGD
Primary source
RGD:727869
See related
EnsemblRapid:ENSRNOG00000012689 AllianceGenome:RGD:727869
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpr136
Summary
Predicted to enable 11-cis retinal binding activity and G protein-coupled photoreceptor activity. Predicted to be involved in several processes, including cellular response to UV; entrainment of circadian clock by photoperiod; and hyaloid vascular plexus regression. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human OPN5 (opsin 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human mouse all
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Genomic context

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See Opn5 in Genome Data Viewer
Location:
9q13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (25865610..25913315)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (18368393..18416098)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (21045457..21092517)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor F2 Neighboring gene adhesion G protein-coupled receptor F4 Neighboring gene transfer RNA threonine (anticodon AGU) 32 Neighboring gene patched domain containing 4 Neighboring gene uncharacterized LOC134480348

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of novel opsins and intrinsic light responses in the mammalian retinal ganglion cell line RGC-5. Presence of OPN5 in the rat retina. Nieto PS, et al. PLoS One, 2011. PMID 22022612, Free PMC Article
  2. UV-sensitive photoreceptor protein OPN5 in humans and mice. Kojima D, et al. PLoS One, 2011. PMID 22043319, Free PMC Article
  3. Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation. Yamashita T, et al. J Biol Chem, 2014 Feb 14. PMID 24403072, Free PMC Article
  4. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. Fredriksson R, et al. FEBS Lett, 2003 Nov 20. PMID 14623098
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The presence of Opn5 in the ganglion cell layer of the rat retina suggests the existence of a novel type of photoreceptor cell.
    Title: Expression of novel opsins and intrinsic light responses in the mammalian retinal ganglion cell line RGC-5. Presence of OPN5 in the rat retina.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 11-cis retinal binding ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled photoreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled photoreceptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to UV-A ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to light stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to light stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in detection of visible light IEA
Inferred from Electronic Annotation
more info
  
involved_in entrainment of circadian clock by photoperiod ISO
Inferred from Sequence Orthology
more info
  
involved_in hyaloid vascular plexus regression ISO
Inferred from Sequence Orthology
more info
  
involved_in phototransduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phototransduction ISO
Inferred from Sequence Orthology
more info
  
involved_in phototransduction, UV ISO
Inferred from Sequence Orthology
more info
  
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
opsin-5
Names
G protein-coupled receptor 136

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389270.1 → NP_001376199.1  opsin-5

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I5ZTV0, A6JJ51
    Related
    ENSRNOP00000080812.1, ENSRNOT00000106707.2
    Conserved Domains (1) summary
    cd15074
    Location:34 → 316
    7tmA_Opsin5_neuropsin; neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    25865610..25913315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083542.2 → XP_038939470.1  opsin-5 isoform X1

    UniProtKB/TrEMBL
    A0A8J8YD44, E9PTI9, Q7TQN6
    Related
    ENSRNOP00000030570.6, ENSRNOT00000031759.7
    Conserved Domains (1) summary
    cd15074
    Location:34 → 353
    7tmA_Opsin5_neuropsin; neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181772.1: Suppressed sequence

    Description
    NM_181772.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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