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Paqr8 progestin and adipoQ receptor family member 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316275, updated on 17-Aug-2024

Summary

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Official Symbol
Paqr8provided by RGD
Official Full Name
progestin and adipoQ receptor family member 8provided by RGD
Primary source
RGD:1311710
See related
EnsemblRapid:ENSRNOG00000067120 AllianceGenome:RGD:1311710
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pmrbeta; RGD1311710
Summary
Predicted to enable steroid binding activity and steroid hormone receptor activity. Predicted to be involved in response to steroid hormone. Predicted to be located in Golgi apparatus. Predicted to be active in plasma membrane. Orthologous to human PAQR8 (progestin and adipoQ receptor family member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 238.9), Testes (RPKM 92.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Paqr8 in Genome Data Viewer
Location:
9q13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (30808921..30858599)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (23312521..23362175)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (27005270..27054591)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480351 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102549795 Neighboring gene EF-hand domain containing 1 Neighboring gene translocation associated membrane protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression and regulation of progestin membrane receptors in the rat corpus luteum. Cai Z, et al. Endocrinology, 2005 Dec. PMID 16123161
  2. Distribution of mRNAs encoding classical progestin receptor, progesterone membrane components 1 and 2, serpine mRNA binding protein 1, and progestin and ADIPOQ receptor family members 7 and 8 in rat forebrain. Intlekofer KA, et al. Neuroscience, 2011 Jan 13. PMID 20977928, Free PMC Article
  3. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PAQR8 and PAQR9 expression is altered in the ventral tegmental area of aged rats infected with varicella zoster virus.
    Title: PAQR8 and PAQR9 expression is altered in the ventral tegmental area of aged rats infected with varicella zoster virus.
  2. Expression patterns of Paqr8 is low and homogeneous in the hypothalamus and more abundant in thalamic nuclei, and is likely to regulate sensory and cognitive functions in forebrain tissues of female rats.
    Title: Distribution of mRNAs encoding classical progestin receptor, progesterone membrane components 1 and 2, serpine mRNA binding protein 1, and progestin and ADIPOQ receptor family members 7 and 8 in rat forebrain.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear steroid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in response to steroid hormone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in steroid hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
membrane progestin receptor beta
Names
progestin and adipoQ receptor family member VIII
progestin membrane receptor beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014099.2 → NP_001014121.1  membrane progestin receptor beta

    See identical proteins and their annotated locations for NP_001014121.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I5XVB9, Q6AY03
    Related
    ENSRNOP00000094604.1, ENSRNOT00000107820.2
    Conserved Domains (1) summary
    pfam03006
    Location:70 → 297
    HlyIII; Haemolysin-III related

  2. NM_001432946.1 → NP_001419875.1  membrane progestin receptor beta

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

  3. NM_001432947.1 → NP_001419876.1  membrane progestin receptor beta

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

  4. NM_001432950.1 → NP_001419879.1  membrane progestin receptor beta

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

  5. NM_001432951.1 → NP_001419880.1  membrane progestin receptor beta

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

  6. NM_001432952.1 → NP_001419881.1  membrane progestin receptor beta

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

  7. NM_001432953.1 → NP_001419882.1  membrane progestin receptor beta

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

  8. NM_001432954.1 → NP_001419883.1  membrane progestin receptor beta

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

  9. NM_001432955.1 → NP_001419884.1  membrane progestin receptor beta

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

  10. NM_001432956.1 → NP_001419885.1  membrane progestin receptor beta

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

  11. NM_001432957.1 → NP_001419886.1  membrane progestin receptor beta

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    30808921..30858599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267116.1 → XP_063123186.1  membrane progestin receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVB9, Q6AY03

  2. XM_017596433.3 → XP_017451922.1  membrane progestin receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVB9, Q6AY03
    Related
    ENSRNOP00000086728.1, ENSRNOT00000107525.2
    Conserved Domains (1) summary
    pfam03006
    Location:70 → 297
    HlyIII; Haemolysin-III related

  3. XM_039083548.2 → XP_038939476.1  membrane progestin receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVB9, Q6AY03
    Conserved Domains (1) summary
    pfam03006
    Location:70 → 297
    HlyIII; Haemolysin-III related

  4. XM_063267123.1 → XP_063123193.1  membrane progestin receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVB9, Q6AY03

  5. XM_063267124.1 → XP_063123194.1  membrane progestin receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVB9, Q6AY03

  6. XM_063267118.1 → XP_063123188.1  membrane progestin receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVB9, Q6AY03

  7. XM_063267120.1 → XP_063123190.1  membrane progestin receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVB9, Q6AY03
    Related
    ENSRNOP00000076707.1, ENSRNOT00000100549.2

  8. XM_063267117.1 → XP_063123187.1  membrane progestin receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVB9, Q6AY03

  9. XM_017596434.3 → XP_017451923.1  membrane progestin receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVB9, Q6AY03
    Conserved Domains (1) summary
    pfam03006
    Location:70 → 297
    HlyIII; Haemolysin-III related

  10. XM_039083545.2 → XP_038939473.1  membrane progestin receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVB9, Q6AY03
    Related
    ENSRNOP00000108197.1, ENSRNOT00000170502.1
    Conserved Domains (1) summary
    pfam03006
    Location:70 → 297
    HlyIII; Haemolysin-III related

  11. XM_063267125.1 → XP_063123195.1  membrane progestin receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVB9, Q6AY03

  12. XM_017596435.3 → XP_017451924.1  membrane progestin receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVB9, Q6AY03
    Conserved Domains (1) summary
    pfam03006
    Location:70 → 297
    HlyIII; Haemolysin-III related

  13. XM_039083547.2 → XP_038939475.1  membrane progestin receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVB9, Q6AY03
    Related
    ENSRNOP00000105678.1, ENSRNOT00000124363.1
    Conserved Domains (1) summary
    pfam03006
    Location:70 → 297
    HlyIII; Haemolysin-III related

  14. XM_063267127.1 → XP_063123197.1  membrane progestin receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVB9, Q6AY03

  15. XM_063267119.1 → XP_063123189.1  membrane progestin receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVB9, Q6AY03

  16. XM_063267122.1 → XP_063123192.1  membrane progestin receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVB9, Q6AY03

  17. XM_063267126.1 → XP_063123196.1  membrane progestin receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVB9, Q6AY03

  18. XM_039083546.2 → XP_038939474.1  membrane progestin receptor beta isoform X1

    UniProtKB/TrEMBL
    A0A8I5XVB9, Q6AY03
    Related
    ENSRNOP00000084979.1, ENSRNOT00000114681.2
    Conserved Domains (1) summary
    pfam03006
    Location:70 → 297
    HlyIII; Haemolysin-III related
Nucleotide Protein Strain
Heading Accession and Version

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