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Lgsn lengsin, lens protein with glutamine synthetase domain [ Rattus norvegicus (Norway rat) ]

Gene ID: 316304, updated on 2-Nov-2024

Summary

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Official Symbol
Lgsnprovided by RGD
Official Full Name
lengsin, lens protein with glutamine synthetase domainprovided by RGD
Primary source
RGD:727925
See related
EnsemblRapid:ENSRNOG00000012205 AllianceGenome:RGD:727925
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lgs; Gluld1
Summary
Predicted to enable glutamine synthetase activity. Predicted to be involved in glutamine biosynthetic process. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and membrane. Orthologous to human LGSN (lengsin, lens protein with glutamine synthetase domain). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 8.3) and Liver (RPKM 2.3) See more
Orthologs
human mouse all
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Genomic context

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See Lgsn in Genome Data Viewer
Location:
9q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (40912398..40943955)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (33416362..33447919)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (37458603..37490117)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548289 Neighboring gene protein tyrosine phosphatase 4A1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ubiquitin conjugating enzyme E2 V1, pseudogene 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A role for lengsin, a recruited enzyme, in terminal differentiation in the vertebrate lens. Wyatt K, et al. J Biol Chem, 2008 Mar 7. PMID 18178558, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables glutamine synthetase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamine synthetase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
NOT involved_in glutamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in nitrogen utilization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lengsin
Names
glutamate-ammonia ligase (glutamine synthase) domain containing 1
glutamate-ammonia ligase (glutamine synthetase) domain containing 1
glutamate-ammonia ligase domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181383.2 → NP_852048.1  lengsin

    See identical proteins and their annotated locations for NP_852048.1

    Status: PROVISIONAL

    Source sequence(s)
    AY280501
    UniProtKB/Swiss-Prot
    Q7TT51
    UniProtKB/TrEMBL
    A0A8I6ADX5, A6IN83
    Related
    ENSRNOP00000016316.3, ENSRNOT00000016316.6
    Conserved Domains (3) summary
    COG0174
    Location:128 → 545
    GlnA; Glutamine synthetase [Amino acid transport and metabolism]
    pfam00120
    Location:235 → 559
    Gln-synt_C; Glutamine synthetase, catalytic domain
    pfam03951
    Location:138 → 223
    Gln-synt_N; Glutamine synthetase, beta-Grasp domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    40912398..40943955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596437.2 → XP_017451926.1  lengsin isoform X2

    UniProtKB/Swiss-Prot
    Q7TT51
    UniProtKB/TrEMBL
    A0A8I6ADX5, A6IN83
    Conserved Domains (3) summary
    COG0174
    Location:128 → 545
    GlnA; Glutamine synthetase [Amino acid transport and metabolism]
    pfam00120
    Location:235 → 559
    Gln-synt_C; Glutamine synthetase, catalytic domain
    pfam03951
    Location:138 → 223
    Gln-synt_N; Glutamine synthetase, beta-Grasp domain

  2. XM_017596436.2 → XP_017451925.1  lengsin isoform X1

    UniProtKB/TrEMBL
    A0A8I6ADX5

  3. XM_039083550.1 → XP_038939478.1  lengsin isoform X3

    Conserved Domains (2) summary
    pfam00120
    Location:111 → 435
    Gln-synt_C; Glutamine synthetase, catalytic domain
    pfam03951
    Location:14 → 99
    Gln-synt_N; Glutamine synthetase, beta-Grasp domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TT51.1 GenPept UniProtKB/Swiss-Prot:Q7TT51

Gene LinkOut

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