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Prss40 protease, serine, 40 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316318, updated on 2-Nov-2024

Summary

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Official Symbol
Prss40provided by RGD
Official Full Name
protease, serine, 40provided by RGD
Primary source
RGD:1561330
See related
EnsemblRapid:ENSRNOG00000014001 AllianceGenome:RGD:1561330
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tesp2; RGD1561330
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 37.2) See more
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Genomic context

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See Prss40 in Genome Data Viewer
Location:
9q21
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (44258081..44266893, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (36762170..36770979, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (41061116..41069929, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene protease, serine, 39 Neighboring gene cripto, FRL-1, cryptic family 1 Neighboring gene small nucleolar RNA, H/ACA box 51 Neighboring gene RCC1 and BTB domain containing protein 1, pseudogene 1 Neighboring gene APC membrane recruitment protein 3 Neighboring gene thymosin beta-10-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine protease 40
Names
testicular serine protease 2
NP_001101679.1
XP_038939487.1
XP_063123213.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108209.1 → NP_001101679.1  serine protease 40 precursor

    See identical proteins and their annotated locations for NP_001101679.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473965
    UniProtKB/TrEMBL
    A6INA6, D3ZR46
    Related
    ENSRNOP00000018758.5, ENSRNOT00000018758.7
    Conserved Domains (2) summary
    smart00020
    Location:70 → 310
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:71 → 313
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    44258081..44266893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083559.2 → XP_038939487.1  serine protease 40 isoform X1

    Conserved Domains (1) summary
    cd00190
    Location:2 → 199
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_063267143.1 → XP_063123213.1  serine protease 40 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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