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Hs6st1 heparan sulfate 6-O-sulfotransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316325, updated on 2-Nov-2024

Summary

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Official Symbol
Hs6st1provided by RGD
Official Full Name
heparan sulfate 6-O-sulfotransferase 1provided by RGD
Primary source
RGD:1309218
See related
EnsemblRapid:ENSRNOG00000014516 AllianceGenome:RGD:1309218
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable heparan sulfate 6-O-sulfotransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification and neuron development. Predicted to act upstream of or within blood vessel development; heparan sulfate proteoglycan biosynthetic process; and lung alveolus development. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 15 with or without anosmia. Orthologous to human HS6ST1 (heparan sulfate 6-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 192.8), Lung (RPKM 159.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hs6st1 in Genome Data Viewer
Location:
9q21
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (45779402..45818583)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (38283502..38322684)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (42620006..42659184)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094664 Neighboring gene uncharacterized LOC120094665 Neighboring gene Histone deacetylase 1, pseudogene 10 Neighboring gene UDP-glucose glycoprotein glucosyltransferase 1 Neighboring gene uncharacterized LOC100909803

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism. Tornberg J, et al. Proc Natl Acad Sci U S A, 2011 Jul 12. PMID 21700882, Free PMC Article
  2. The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. Habuchi H, et al. J Biol Chem, 2000 Jan 28. PMID 10644753
  3. Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality. Habuchi H, et al. J Biol Chem, 2007 May 25. PMID 17405882
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heparan sulfate 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparan sulfate 6-O-sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process, enzymatic modification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within labyrinthine layer blood vessel development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lung alveolus development ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heparan-sulfate 6-O-sulfotransferase 1
NP_001101680.1
XP_038939488.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108210.1 → NP_001101680.1  heparan-sulfate 6-O-sulfotransferase 1

    See identical proteins and their annotated locations for NP_001101680.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473965
    UniProtKB/TrEMBL
    A6INC0
    Related
    ENSRNOP00000019966.6, ENSRNOT00000019966.8
    Conserved Domains (1) summary
    pfam03567
    Location:3 → 268
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    45779402..45818583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083560.2 → XP_038939488.1  heparan-sulfate 6-O-sulfotransferase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y4T0
    Related
    ENSRNOP00000076596.1, ENSRNOT00000119852.2
    Conserved Domains (1) summary
    cl22970
    Location:65 → 247
    Sulfotransfer_2; Sulfotransferase family
Nucleotide Protein Strain
Heading Accession and Version

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