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Rev1 REV1, DNA directed polymerase [ Rattus norvegicus (Norway rat) ]

Gene ID: 316344, updated on 10-Oct-2024

Summary

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Official Symbol
Rev1provided by RGD
Official Full Name
REV1, DNA directed polymeraseprovided by RGD
Primary source
RGD:1306715
See related
EnsemblRapid:ENSRNOG00000018623 AllianceGenome:RGD:1306715
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rev1l
Summary
Predicted to enable DNA-directed DNA polymerase activity and deoxycytidyl transferase activity. Predicted to be involved in error-free translesion synthesis; error-prone translesion synthesis; and response to UV. Predicted to be located in nucleus. Orthologous to human REV1 (REV1 DNA directed polymerase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 142.9), Adrenal (RPKM 125.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rev1 in Genome Data Viewer
Location:
9q21
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (47773907..47847554, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (40278100..40351764, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (44714137..44786330, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 9 Neighboring gene eukaryotic translation initiation factor 5B Neighboring gene uncharacterized LOC134480569 Neighboring gene transfer RNA threonine (anticodon AGU) 33 Neighboring gene ALF transcription elongation factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mechanisms of dCMP transferase reactions catalyzed by mouse Rev1 protein. Masuda Y, et al. J Biol Chem, 2002 Jan 25. PMID 11711549
  2. Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7. Murakumo Y, et al. J Biol Chem, 2001 Sep 21. PMID 11485998
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables deoxycytidyl transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deoxycytidyl transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in error-free translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in error-prone translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within error-prone translesion synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA repair protein REV1
Names
REV1 homolog
REV1, polymerase (DNA directed)
REV1-like
NP_001381058.2
XP_008765252.1
XP_017451933.1
XP_017451934.1
XP_017451935.1
XP_038939504.1
XP_038939505.1
XP_038939506.1
XP_038939507.1
XP_038939508.1
XP_063123228.1
XP_063123229.1
XP_063123230.1
XP_063123231.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394129.2 → NP_001381058.2  DNA repair protein REV1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I5ZJ91, D3ZRU9
    Related
    ENSRNOP00000076682.2, ENSRNOT00000111097.2
    Conserved Domains (4) summary
    cd01701
    Location:346 → 822
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:1140 → 1233
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48 → 131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:1004 → 1039
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

RNA

  1. NR_172081.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    47773907..47847554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083577.2 → XP_038939505.1  DNA repair protein REV1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZJ91, D3ZRU9
    Conserved Domains (4) summary
    cd01701
    Location:346 → 822
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:1140 → 1233
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48 → 131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:1004 → 1039
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  2. XM_063267161.1 → XP_063123231.1  DNA repair protein REV1 isoform X4

  3. XM_039083578.2 → XP_038939506.1  DNA repair protein REV1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZJ91, D3ZRU9
    Conserved Domains (4) summary
    cd01701
    Location:346 → 822
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:1140 → 1233
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48 → 131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:1004 → 1039
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  4. XM_039083576.2 → XP_038939504.1  DNA repair protein REV1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZJ91, D3ZRU9
    Conserved Domains (4) summary
    cd01701
    Location:346 → 822
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:1140 → 1233
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48 → 131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:1004 → 1039
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  5. XM_063267160.1 → XP_063123230.1  DNA repair protein REV1 isoform X3

  6. XM_063267159.1 → XP_063123229.1  DNA repair protein REV1 isoform X2

  7. XM_063267158.1 → XP_063123228.1  DNA repair protein REV1 isoform X1

    UniProtKB/TrEMBL
    D3ZRU9

  8. XM_039083579.1 → XP_038939507.1  DNA repair protein REV1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZJ91, D3ZRU9
    Conserved Domains (4) summary
    cd01701
    Location:346 → 822
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:1140 → 1233
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48 → 131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:1004 → 1039
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  9. XM_039083580.1 → XP_038939508.1  DNA repair protein REV1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZJ91, D3ZRU9
    Conserved Domains (4) summary
    cd01701
    Location:346 → 822
    PolY_Rev1; DNA polymerase Rev1
    cd12145
    Location:1140 → 1233
    Rev1_C; C-terminal domain of the Y-family polymerase Rev1
    cd17719
    Location:48 → 131
    BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins
    cd19318
    Location:1004 → 1039
    Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

  10. XM_008767030.3 → XP_008765252.1  DNA repair protein REV1 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZJ91
    Conserved Domains (4) summary
    cd01701
    Location:131 → 607
    PolY_Rev1; DNA polymerase Rev1
    PRK14133
    Location:202 → 607
    PRK14133; DNA polymerase IV; Provisional
    pfam14377
    Location:721 → 841
    DUF4414; Domain of unknown function (DUF4414)
    pfam16727
    Location:897 → 1018
    REV1_C; DNA repair protein REV1 C-terminal domain

  11. XM_017596445.3 → XP_017451934.1  DNA repair protein REV1 isoform X6

  12. XM_017596444.3 → XP_017451933.1  DNA repair protein REV1 isoform X6

  13. XM_017596446.2 → XP_017451935.1  DNA repair protein REV1 isoform X6

RNA

  1. XR_010054595.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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