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Farp2 FERM, ARH/RhoGEF and pleckstrin domain protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316639, updated on 2-Nov-2024

Summary

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Official Symbol
Farp2provided by RGD
Official Full Name
FERM, ARH/RhoGEF and pleckstrin domain protein 2provided by RGD
Primary source
RGD:1308003
See related
EnsemblRapid:ENSRNOG00000018051 AllianceGenome:RGD:1308003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including osteoclast differentiation; podosome assembly; and regulation of integrin activation. Predicted to act upstream of or within Rac protein signal transduction; hair cycle process; and neuron remodeling. Predicted to be located in cytoplasm. Orthologous to human FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 113.4), Kidney (RPKM 104.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Farp2 in Genome Data Viewer
Location:
9q36
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (101501061..101609092)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (94053650..94161982)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (100660366..100767940)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene high density lipoprotein binding protein Neighboring gene uncharacterized LOC120094809 Neighboring gene septin 2 Neighboring gene 5S ribosomal RNA Neighboring gene serine/threonine kinase 25 Neighboring gene BCL2 family apoptosis regulator BOK

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Integral roles of a guanine nucleotide exchange factor, FARP2, in osteoclast podosome rearrangements. Takegahara N, et al. FASEB J, 2010 Dec. PMID 20702777
  2. Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2. He X, et al. Structure, 2013 Mar 5. PMID 23375260, Free PMC Article
  3. A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling. Kubo T, et al. J Neurosci, 2002 Oct 1. PMID 12351724, Free PMC Article
  4. Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. DiTommaso T, et al. PLoS Genet, 2014 Oct. PMID 25340873, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hair cycle process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in podosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of integrin activation ISO
Inferred from Sequence Orthology
more info
  
involved_in semaphorin-plexin signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FERM, ARHGEF and pleckstrin domain-containing protein 2
Names
FERM, RhoGEF and pleckstrin domain protein 2
FERM, RhoGEF and pleckstrin domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108233.2 → NP_001101703.1  FERM, ARHGEF and pleckstrin domain-containing protein 2

    See identical proteins and their annotated locations for NP_001101703.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A6JR19, D3ZFK8
    Conserved Domains (6) summary
    smart00295
    Location:45 → 234
    B41; Band 4.1 homologues
    cd00160
    Location:539 → 718
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01220
    Location:747 → 853
    PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
    cd13193
    Location:221 → 341
    FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
    cd13235
    Location:924 → 1021
    PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
    pfam08736
    Location:333 → 375
    FA; FERM adjacent (FA)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    101501061..101609092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083771.2 → XP_038939699.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6JR19, D3ZFK8
    Conserved Domains (6) summary
    smart00295
    Location:45 → 234
    B41; Band 4.1 homologues
    cd00160
    Location:539 → 718
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01220
    Location:747 → 853
    PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
    cd13193
    Location:221 → 341
    FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
    cd13235
    Location:924 → 1021
    PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
    pfam08736
    Location:333 → 375
    FA; FERM adjacent (FA)

  2. XM_039083770.2 → XP_038939698.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6JR19, D3ZFK8
    Related
    ENSRNOP00000024440.5, ENSRNOT00000024440.7
    Conserved Domains (6) summary
    smart00295
    Location:45 → 234
    B41; Band 4.1 homologues
    cd00160
    Location:539 → 718
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01220
    Location:747 → 853
    PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
    cd13193
    Location:221 → 341
    FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
    cd13235
    Location:924 → 1021
    PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
    pfam08736
    Location:333 → 375
    FA; FERM adjacent (FA)

  3. XM_063267327.1 → XP_063123397.1  FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A6JR19, D3ZFK8
Nucleotide Protein Strain
Heading Accession and Version

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