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Etfbkmt electron transfer flavoprotein subunit beta lysine methyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 316976, updated on 21-Sep-2024

Summary

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Official Symbol
Etfbkmtprovided by RGD
Official Full Name
electron transfer flavoprotein subunit beta lysine methyltransferaseprovided by RGD
Primary source
RGD:735147
See related
EnsemblRapid:ENSRNOG00000036918 AllianceGenome:RGD:735147
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mettl20; ETFB-KMT
Summary
Predicted to enable heat shock protein binding activity and protein-lysine N-methyltransferase activity. Predicted to be involved in negative regulation of electron transfer activity; negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase; and peptidyl-lysine trimethylation. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrial matrix. Orthologous to human ETFBKMT (electron transfer flavoprotein subunit beta lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 121.0), Spleen (RPKM 105.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Etfbkmt in Genome Data Viewer
Location:
4q44
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (183871819..183936843)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (182140492..182204635)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (183655968..183665757)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene DENN domain containing 5B Neighboring gene U6 spliceosomal RNA Neighboring gene mesoderm specific transcript, pseudogene 1 Neighboring gene antagonist of mitotic exit network 1 homolog Neighboring gene adenosylhomocysteinase-like Neighboring gene basic transcription factor 3, pseudogene 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human METTL20 methylates lysine residues adjacent to the recognition loop of the electron transfer flavoprotein in mitochondria. Rhein VF, et al. J Biol Chem, 2014 Aug 29. PMID 25023281, Free PMC Article
  2. Human METTL20 is a mitochondrial lysine methyltransferase that targets the β subunit of electron transfer flavoprotein (ETFβ) and modulates its activity. Małecki J, et al. J Biol Chem, 2015 Jan 2. PMID 25416781, Free PMC Article
  3. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. Cloutier P, et al. PLoS Genet, 2013. PMID 23349634, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC72974

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-lysine N-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-lysine trimethylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-lysine trimethylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
electron transfer flavoprotein beta subunit lysine methyltransferase
Names
ETFB lysine methyltransferase
methyltransferase like 20
methyltransferase-like protein 20
protein N-lysine methyltransferase METTL20
NP_942067.1
XP_006237763.1
XP_038963650.1
XP_038963652.1
XP_038963653.1
XP_063142266.1
XP_063142267.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198772.2 → NP_942067.1  electron transfer flavoprotein beta subunit lysine methyltransferase

    See identical proteins and their annotated locations for NP_942067.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q6P7Q0
    Related
    ENSRNOP00000052309.2, ENSRNOT00000055442.4
    Conserved Domains (1) summary
    cl17173
    Location:58 → 253
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    183871819..183936843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107724.2 → XP_038963652.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:58 → 158
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_039107725.2 → XP_038963653.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform X3

    Conserved Domains (1) summary
    cl17173
    Location:58 → 168
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. XM_039107722.2 → XP_038963650.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q6P7Q0
    Conserved Domains (1) summary
    cl17173
    Location:58 → 253
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  4. XM_063286197.1 → XP_063142267.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform X4

  5. XM_063286196.1 → XP_063142266.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform X2

  6. XM_006237701.5 → XP_006237763.1  electron transfer flavoprotein beta subunit lysine methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006237763.1

    UniProtKB/Swiss-Prot
    Q6P7Q0
    Conserved Domains (1) summary
    cl17173
    Location:58 → 253
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P7Q0.1 GenPept UniProtKB/Swiss-Prot:Q6P7Q0

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