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Morf4l2 mortality factor 4 like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 317413, updated on 14-Nov-2024

Summary

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Official Symbol
Morf4l2provided by RGD
Official Full Name
mortality factor 4 like 2provided by RGD
Primary source
RGD:1359471
See related
EnsemblRapid:ENSRNOG00000002389 AllianceGenome:RGD:1359471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LRRG00119
Summary
Acts upstream of or within positive regulation of striated muscle cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleolus; nucleoplasm; and plasma membrane. Predicted to be part of NuA4 histone acetyltransferase complex and nucleosome. Orthologous to human MORF4L2 (mortality factor 4 like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 2136.3), Brain (RPKM 908.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Morf4l2 in Genome Data Viewer
Location:
Xq32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (104874850..104885946, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (100082562..100093658, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (107394468..107405564, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene acyl-protein thioesterase 1-like Neighboring gene transcription elongation factor A like 1 Neighboring gene uncharacterized LOC102555540 Neighboring gene glycine receptor alpha 4 Neighboring gene proteolipid protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. Tominaga K, et al. J Biol Chem, 2003 Dec 5. PMID 14506250
  2. Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation. Kee HJ, et al. J Biol Chem, 2007 Mar 9. PMID 17192267
  3. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21502417
  4. A visual intracellular classification strategy for uncharacterized human proteins. Hoja MR, et al. Exp Cell Res, 2000 Aug 25. PMID 10942595
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC93688, MGC94357

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of striated muscle cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mortality factor 4-like protein 2
Names
MORF-related gene X protein
liver regeneration-related protein LRRG00119
transcription factor-like protein MRGX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007714.2 → NP_001007715.1  mortality factor 4-like protein 2

    See identical proteins and their annotated locations for NP_001007715.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    Q6QI89
    UniProtKB/TrEMBL
    A6KNT3
    Related
    ENSRNOP00000077798.1, ENSRNOT00000093840.2
    Conserved Domains (2) summary
    PLN02967
    Location:1 → 150
    PLN02967; kinase
    pfam05712
    Location:110 → 276
    MRG

  2. NM_001434138.1 → NP_001421067.1  mortality factor 4-like protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  3. NM_001434139.1 → NP_001421068.1  mortality factor 4-like protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  4. NM_001434140.1 → NP_001421069.1  mortality factor 4-like protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  5. NM_001434141.1 → NP_001421070.1  mortality factor 4-like protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  6. NM_001434142.1 → NP_001421071.1  mortality factor 4-like protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  7. NM_001434143.1 → NP_001421072.1  mortality factor 4-like protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    104874850..104885946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006257296.5 → XP_006257358.1  mortality factor 4-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6QI89
    UniProtKB/TrEMBL
    A6KNT3
    Conserved Domains (2) summary
    PLN02967
    Location:1 → 150
    PLN02967; kinase
    pfam05712
    Location:110 → 276
    MRG

  2. XM_039099802.2 → XP_038955730.1  mortality factor 4-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6QI89
    UniProtKB/TrEMBL
    A6KNT3
    Conserved Domains (2) summary
    PLN02967
    Location:1 → 150
    PLN02967; kinase
    pfam05712
    Location:110 → 276
    MRG

  3. XM_006257295.4 → XP_006257357.1  mortality factor 4-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6QI89
    UniProtKB/TrEMBL
    A6KNT3
    Related
    ENSRNOP00000081349.1, ENSRNOT00000108536.2
    Conserved Domains (2) summary
    PLN02967
    Location:1 → 150
    PLN02967; kinase
    pfam05712
    Location:110 → 276
    MRG

  4. XM_006257297.4 → XP_006257359.1  mortality factor 4-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6QI89
    UniProtKB/TrEMBL
    A6KNT3
    Related
    ENSRNOP00000084568.1, ENSRNOT00000108398.2
    Conserved Domains (2) summary
    PLN02967
    Location:1 → 150
    PLN02967; kinase
    pfam05712
    Location:110 → 276
    MRG
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6QI89.1 GenPept UniProtKB/Swiss-Prot:Q6QI89

Gene LinkOut

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