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Wwc3 WWC family member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 317439, updated on 2-Nov-2024

Summary

Official Symbol
Wwc3provided by RGD
Official Full Name
WWC family member 3provided by RGD
Primary source
RGD:1560666
See related
EnsemblRapid:ENSRNOG00000024250 AllianceGenome:RGD:1560666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560666
Summary
Predicted to enable kinase binding activity and signaling adaptor activity. Predicted to be involved in several processes, including hippo signaling; negative regulation of hippo signaling; and negative regulation of organ growth. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human WWC3 (WWC family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 118.0), Lung (RPKM 115.5) and 9 other tissues See more
Orthologs
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Genomic context

See Wwc3 in Genome Data Viewer
Location:
Xq13
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (27146018..27263446)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (23584204..23701864)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (24872496..24988671)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547980 Neighboring gene uncharacterized LOC120099309 Neighboring gene spermatogenesis associated multipass transmembrane protein 2 Neighboring gene chloride voltage-gated channel 4 Neighboring gene uncharacterized LOC120099331

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hippo signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of organ growth IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of organ growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427611.1NP_001414540.1  protein WWC3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    M0R8P6
    Related
    ENSRNOP00000065846.4, ENSRNOT00000071173.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    27146018..27263446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)