U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Egfl6 EGF-like-domain, multiple 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 317470, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Egfl6provided by RGD
Official Full Name
EGF-like-domain, multiple 6provided by RGD
Primary source
RGD:1563321
See related
EnsemblRapid:ENSRNOG00000004275 AllianceGenome:RGD:1563321
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity and integrin binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Predicted to be located in basement membrane. Orthologous to human EGFL6 (EGF like domain multiple 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 341.4) and Kidney (RPKM 39.1) See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Egfl6 in Genome Data Viewer
Location:
Xq13
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (31515752..31573699)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (27884087..27942044)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (29430789..29488737)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551617 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene transcription elongation factor A N-terminal and central domain containing Neighboring gene stabilizer of axonemal microtubules like 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
epidermal growth factor-like protein 6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108254.1 → NP_001101724.1  epidermal growth factor-like protein 6 precursor

    See identical proteins and their annotated locations for NP_001101724.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474014
    UniProtKB/TrEMBL
    A0A0G2KB47, A6K2H3, D3Z8B8
    Related
    ENSRNOP00000062411.3, ENSRNOT00000068337.5
    Conserved Domains (3) summary
    cd06263
    Location:394 → 507
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00179
    Location:172 → 205
    EGF_CA; Calcium-binding EGF-like domain
    pfam12947
    Location:221 → 256
    EGF_3; EGF domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    31515752..31573699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099835.2 → XP_038955763.1  epidermal growth factor-like protein 6 isoform X1

    Conserved Domains (4) summary
    smart00179
    Location:92 → 123
    EGF_CA; Calcium-binding EGF-like domain
    pfam07645
    Location:172 → 207
    EGF_CA; Calcium-binding EGF domain
    pfam12947
    Location:221 → 256
    EGF_3; EGF domain
    cl27660
    Location:400 → 419
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

  2. XM_039099836.2 → XP_038955764.1  epidermal growth factor-like protein 6 isoform X2

    Conserved Domains (4) summary
    smart00179
    Location:92 → 123
    EGF_CA; Calcium-binding EGF-like domain
    pfam07645
    Location:172 → 207
    EGF_CA; Calcium-binding EGF domain
    pfam12947
    Location:221 → 256
    EGF_3; EGF domain
    cl27660
    Location:399 → 418
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools