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Atp11c ATPase phospholipid transporting 11C [ Rattus norvegicus (Norway rat) ]

Gene ID: 317599, updated on 28-Oct-2024

Summary

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Official Symbol
Atp11cprovided by RGD
Official Full Name
ATPase phospholipid transporting 11Cprovided by RGD
Primary source
RGD:1564481
See related
EnsemblRapid:ENSRNOG00000003472 AllianceGenome:RGD:1564481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Atp11c-ps1; RGD1564481
Summary
Predicted to enable phosphatidylethanolamine flippase activity and phosphatidylserine flippase activity. Predicted to be involved in phospholipid translocation; positive regulation of B cell differentiation; and pre-B cell differentiation. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in endoplasmic reticulum; plasma membrane; and recycling endosome. Human ortholog(s) of this gene implicated in X-linked congenital hemolytic anemia. Orthologous to human ATP11C (ATPase phospholipid transporting 11C). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Liver (RPKM 422.7), Lung (RPKM 77.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Atp11c in Genome Data Viewer
Location:
Xq36
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (143600763..143788407, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (138564459..138752116, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (143340712..143525588, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene coagulation factor IX Neighboring gene MCF.2 cell line derived transforming sequence Neighboring gene microRNA 3589 Neighboring gene microRNA 505 Neighboring gene similar to human chromosome X open reading frame 66 Neighboring gene HUWE1 associated protein modifying stress responses 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes. Yabas M, et al. Nat Immunol, 2011 May. PMID 21423173, Free PMC Article
  2. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. Takatsu H, et al. J Biol Chem, 2011 Nov 4. PMID 21914794, Free PMC Article
  3. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylethanolamine flippase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine flippase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in aminophospholipid translocation IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid translocation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in pre-B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATPase phospholipid transporting 11C; phospholipid-transporting ATPase IG
Names
ATPase, class VI, type 11C, pseudogene 1
XP_006257659.1
XP_006257661.1
XP_017457898.1
XP_017457899.1
XP_038956371.1
XP_038956372.1
XP_038956373.1
XP_038956374.1
XP_038956375.1
XP_038956376.1
XP_038956377.1
XP_063136640.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433005.1 → NP_001419934.1  ATPase phospholipid transporting 11C isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A8I5ZV31

  2. NM_001433006.1 → NP_001419935.1  ATPase phospholipid transporting 11C isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

  3. NM_001433007.1 → NP_001419936.1  ATPase phospholipid transporting 11C isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A8I6AFP3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    143600763..143788407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039100444.2 → XP_038956372.1  phospholipid-transporting ATPase IG isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZV31, A0A8I5ZVG5
    Conserved Domains (2) summary
    cd02073
    Location:42 → 974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam16212
    Location:862 → 1090
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

  2. XM_039100447.2 → XP_038956375.1  phospholipid-transporting ATPase IG isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZV31, A0A8I5ZVG5
    Related
    ENSRNOP00000104854.1, ENSRNOT00000151260.1
    Conserved Domains (2) summary
    cd02073
    Location:42 → 974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam16212
    Location:862 → 1090
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

  3. XM_039100445.2 → XP_038956373.1  phospholipid-transporting ATPase IG isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZV31, A0A8I5ZVG5
    Related
    ENSRNOP00000093385.1, ENSRNOT00000109683.2
    Conserved Domains (2) summary
    cd02073
    Location:42 → 974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam16212
    Location:862 → 1090
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

  4. XM_039100446.2 → XP_038956374.1  phospholipid-transporting ATPase IG isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZV31, A0A8I5ZVG5
    Related
    ENSRNOP00000081652.2, ENSRNOT00000116612.2
    Conserved Domains (2) summary
    cd02073
    Location:42 → 974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam16212
    Location:862 → 1090
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

  5. XM_039100443.2 → XP_038956371.1  phospholipid-transporting ATPase IG isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZV31, A0A8I5ZVG5
    Related
    ENSRNOP00000092019.2, ENSRNOT00000098851.2
    Conserved Domains (2) summary
    cd02073
    Location:42 → 974
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam16212
    Location:862 → 1090
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

  6. XM_063280570.1 → XP_063136640.1  phospholipid-transporting ATPase IG isoform X5

    Related
    ENSRNOP00000097091.2, ENSRNOT00000107692.2

  7. XM_017602409.3 → XP_017457898.1  phospholipid-transporting ATPase IG isoform X3

    UniProtKB/TrEMBL
    D3ZFC5
    Conserved Domains (2) summary
    cd02073
    Location:43 → 975
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam16212
    Location:863 → 1091
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

  8. XM_017602410.3 → XP_017457899.1  phospholipid-transporting ATPase IG isoform X6

    UniProtKB/TrEMBL
    D3ZFC5
    Conserved Domains (2) summary
    cd02073
    Location:43 → 975
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam16212
    Location:863 → 1091
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

  9. XM_006257597.5 → XP_006257659.1  phospholipid-transporting ATPase IG isoform X4

    See identical proteins and their annotated locations for XP_006257659.1

    UniProtKB/TrEMBL
    D3ZFC5
    Conserved Domains (6) summary
    TIGR01652
    Location:41 → 1089
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:98 → 183
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:469 → 573
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:38 → 91
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:863 → 1090
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:812 → 841
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  10. XM_006257599.5 → XP_006257661.1  phospholipid-transporting ATPase IG isoform X1

    See identical proteins and their annotated locations for XP_006257661.1

    UniProtKB/TrEMBL
    A0A8I5ZVG5, A0A8I6AUH5
    Related
    ENSRNOP00000100298.1, ENSRNOT00000137722.1
    Conserved Domains (6) summary
    TIGR01652
    Location:41 → 1089
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:98 → 183
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:469 → 573
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:38 → 91
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:863 → 1090
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:812 → 841
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  11. XM_039100448.2 → XP_038956376.1  phospholipid-transporting ATPase IG isoform X3

    UniProtKB/TrEMBL
    D3ZFC5
    Conserved Domains (2) summary
    cd02073
    Location:43 → 975
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam16212
    Location:863 → 1091
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

  12. XM_039100449.2 → XP_038956377.1  phospholipid-transporting ATPase IG isoform X6

    UniProtKB/TrEMBL
    D3ZFC5
    Conserved Domains (2) summary
    cd02073
    Location:43 → 975
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    pfam16212
    Location:863 → 1091
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
Nucleotide Protein Strain
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