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POTED POTE ankyrin domain family member D [ Homo sapiens (human) ]

Gene ID: 317754, updated on 3-Apr-2024

Summary

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Official Symbol
POTEDprovided by HGNC
Official Full Name
POTE ankyrin domain family member Dprovided by HGNC
Primary source
HGNC:HGNC:23822
See related
Ensembl:ENSG00000166351 MIM:607549; AllianceGenome:HGNC:23822
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POTE; A26B3; POTE21; ANKRD21; CT104.1; POTE-21
Summary
Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 4.0) See more
Orthologs
all
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Genomic context

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Location:
21q11.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (13609777..13645823)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (11954085..11990156)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (14982098..15018144)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1674 Neighboring gene olfactory receptor family 4 subfamily K member 12 pseudogene Neighboring gene RNA, U6 small nuclear 286, pseudogene Neighboring gene microRNA 3118-1 Neighboring gene GRAM domain containing 4 pseudogene 1 Neighboring gene CXADR pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study suggests POTE may have a role in apoptosis in the human testis.
    Title: POTE protein, a cancer-testis antigen, is highly expressed in spermatids in human testis and is associated with apoptotic cells.
  2. By immunohistochemistry we demonstrated that the POTE protein is expressed in primary spermatocytes, implying a role in spermatogenesis.
    Title: Expression of POTE protein in human testis detected by novel monoclonal antibodies.
  3. POTE protein isoforms were characterized and may have important signaling function in the reproductive system.
    Title: Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
POTE ankyrin domain family member D
Names
ANKRD26-like family B member 3
Expressed in prostate, ovary, testis, and placenta
ankyrin repeat domain 21
ankyrin repeat domain-containing protein 21
cancer/testis antigen family 104, member 1
prostate, ovary, testis-expressed protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174981.6 → NP_778146.2  POTE ankyrin domain family member D

    See identical proteins and their annotated locations for NP_778146.2

    Status: VALIDATED

    Source sequence(s)
    AP001465
    Consensus CDS
    CCDS13562.1
    UniProtKB/Swiss-Prot
    C9JCF7, Q86YR6
    UniProtKB/TrEMBL
    A0A087X187
    Related
    ENSP00000299443.5, ENST00000299443.6
    Conserved Domains (5) summary
    cd00204
    Location:167 → 292
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR04211
    Location:440 → 556
    SH3_and_anchor; SH3 domain protein
    pfam12796
    Location:177 → 269
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:143 → 193
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:174 → 203
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    13609777..13645823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723997.4 → XP_006724060.1  POTE ankyrin domain family member D isoform X1

    See identical proteins and their annotated locations for XP_006724060.1

    UniProtKB/TrEMBL
    D7UEQ8
    Conserved Domains (4) summary
    cd00204
    Location:167 → 292
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:177 → 269
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:143 → 193
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:174 → 203
    ANK; ANK repeat [structural motif]

  2. XM_011529550.3 → XP_011527852.1  POTE ankyrin domain family member D isoform X2

    UniProtKB/TrEMBL
    A0A087X1W7
    Related
    ENSP00000484512.1, ENST00000620442.4
    Conserved Domains (4) summary
    cd00204
    Location:167 → 292
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:177 → 269
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:143 → 193
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:174 → 203
    ANK; ANK repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    11954085..11990156
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324459.1 → XP_054180434.1  POTE ankyrin domain family member D isoform X1

  2. XM_054324460.1 → XP_054180435.1  POTE ankyrin domain family member D isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86YR6.2 GenPept UniProtKB/Swiss-Prot:Q86YR6

Gene LinkOut

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