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H2bc22 H2B clustered histone 22 [ Mus musculus (house mouse) ]

Gene ID: 319188, updated on 2-Nov-2024

Summary

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Official Symbol
H2bc22provided by MGI
Official Full Name
H2B clustered histone 22provided by MGI
Primary source
MGI:MGI:2448409
See related
Ensembl:ENSMUSG00000069308 AllianceGenome:MGI:2448409
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hist1h2bp
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Aug 2015]
Expression
Broad expression in thymus adult (RPKM 257.9), colon adult (RPKM 133.4) and 23 other tissues See more
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Genomic context

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See H2bc22 in Genome Data Viewer
Location:
13 A3.1; 13 7.97 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (21971652..21985731)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21787483..21801561)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1456 Neighboring gene H3 clustered histone 11 Neighboring gene STARR-seq mESC enhancer starr_33864 Neighboring gene H2A clustered histone 22 Neighboring gene STARR-positive B cell enhancer mm9_chr13:21894945-21895245 Neighboring gene H2B clustered histone 23 Neighboring gene H2A clustered histone 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of a novel histone 2B during mouse spermiogenesis. Moss SB, et al. Dev Biol, 1989 May. PMID 2707490
  2. Phosphorylation of histone H2B at DNA double-strand breaks. Fernandez-Capetillo O, et al. J Exp Med, 2004 Jun 21. PMID 15197225, Free PMC Article
  3. Histone modifications associated with somatic hypermutation. Odegard VH, et al. Immunity, 2005 Jul. PMID 16039583
  4. Histone H2B as a functionally important plasminogen receptor on macrophages. Das R, et al. Blood, 2007 Nov 15. PMID 17690254, Free PMC Article
  5. The human and mouse replication-dependent histone genes. Marzluff WF, et al. Genomics, 2002 Nov. PMID 12408966

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histone H2B type 1-P
Names
histone 1, H2bp
histone cluster 1, H2bp

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290466.1 → NP_001277395.1  histone H2B type 1-P isoform 2

    See identical proteins and their annotated locations for NP_001277395.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is intronless and contains a palindromic termination sequence instead of a polyA signal and tail, compared to variant 1. It encodes isoform 2 which has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AL589651
    Consensus CDS
    CCDS79168.1
    UniProtKB/Swiss-Prot
    Q64477, Q6P8V8, Q8CGP2
    UniProtKB/TrEMBL
    A0JLV3
    Related
    ENSMUSP00000100047.2, ENSMUST00000102982.2
    Conserved Domains (1) summary
    smart00427
    Location:28 → 124
    H2B; Histone H2B

  2. NM_178202.2 → NP_835509.2  histone H2B type 1-P isoform 1

    See identical proteins and their annotated locations for NP_835509.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AV047260, BC061044
    Consensus CDS
    CCDS26298.2
    UniProtKB/TrEMBL
    A0JLV3
    Related
    ENSMUSP00000106099.3, ENSMUST00000110473.3
    Conserved Domains (2) summary
    pfam00125
    Location:3 → 102
    Histone; Core histone H2A/H2B/H3/H4
    cl23830
    Location:12 → 125
    H2B; Histone H2B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    21971652..21985731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516690.4 → XP_006516753.1  histone H2B type 1-P isoform X1

    See identical proteins and their annotated locations for XP_006516753.1

    UniProtKB/Swiss-Prot
    Q64477, Q6P8V8, Q8CGP2
    UniProtKB/TrEMBL
    A0JLV3
    Conserved Domains (1) summary
    smart00427
    Location:28 → 124
    H2B; Histone H2B
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CGP2.3 GenPept UniProtKB/Swiss-Prot:Q8CGP2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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