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Trim12c tripartite motif-containing 12C [ Mus musculus (house mouse) ]

Gene ID: 319236, updated on 28-Oct-2024

Summary

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Official Symbol
Trim12cprovided by MGI
Official Full Name
tripartite motif-containing 12Cprovided by MGI
Primary source
MGI:MGI:4821183
See related
Ensembl:ENSMUSG00000057143 AllianceGenome:MGI:4821183
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trim12-2; 9230105E10Rik
Summary
Predicted to enable several functions, including protein homodimerization activity; transcription coactivator activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to symbiont; positive regulation of NF-kappaB transcription factor activity; and regulation of signal transduction. Predicted to be located in P-body. Predicted to be active in cytosol and nucleoplasm. Predicted to colocalize with omegasome. Is expressed in genitourinary system. Orthologous to human TRIM5 (tripartite motif containing 5). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 5.3), thymus adult (RPKM 3.9) and 28 other tissues See more
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Genomic context

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See Trim12c in Genome Data Viewer
Location:
7 E3; 7 55.69 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (103987961..104002649, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (104338754..104353358, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6579 Neighboring gene tripartite motif-containing 12A Neighboring gene STARR-positive B cell enhancer ABC_E2840 Neighboring gene STARR-positive B cell enhancer ABC_E876 Neighboring gene predicted gene 15133 Neighboring gene predicted gene, 17788 Neighboring gene tripartite motif-containing 34B Neighboring gene STARR-positive B cell enhancer ABC_E1090 Neighboring gene predicted gene, 36430 Neighboring gene predicted gene, 38525 Neighboring gene tripartite motif-containing 30B Neighboring gene STARR-positive B cell enhancer ABC_E8194 Neighboring gene tripartite motif-containing 30C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tripartite Motif (TRIM) 12c, a Mouse Homolog of TRIM5, Is a Ubiquitin Ligase That Stimulates Type I IFN and NF-κB Pathways along with TNFR-Associated Factor 6. Chang TH, et al. J Immunol, 2015 Dec 1. PMID 26503954, Free PMC Article
  2. Mapping of susceptibility loci for Ebola virus pathogenesis in mice. Schäfer A, et al. Cell Rep, 2024 May 28. PMID 38652660, Free PMC Article
  3. An expanded clade of rodent Trim5 genes. Tareen SU, et al. Virology, 2009 Mar 15. PMID 19147168, Free PMC Article
  4. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study identifies TRIM12c as a mouse TRIM5 equivalent, critical for host innate immunity.
    Title: Tripartite Motif (TRIM) 12c, a Mouse Homolog of TRIM5, Is a Ubiquitin Ligase That Stimulates Type I IFN and NF-κB Pathways along with TNFR-Associated Factor 6.
  2. describe an expanded paralogous cluster of at least eight Trim5-like genes in mice
    Title: An expanded clade of rodent Trim5 genes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables pattern recognition receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in suppression of viral release by host ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with omegasome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tripartite motif-containing 12C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146007.1 → NP_001139479.1  tripartite motif-containing 12C

    See identical proteins and their annotated locations for NP_001139479.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC142110, AK050485
    Consensus CDS
    CCDS52344.1
    UniProtKB/TrEMBL
    D3Z3L3, E9Q987, Q8CHU6
    Related
    ENSMUSP00000060100.9, ENSMUST00000059037.15
    Conserved Domains (4) summary
    smart00336
    Location:96 → 132
    BBOX; B-Box-type zinc finger
    pfam14265
    Location:164 → 234
    DUF4355; Domain of unknown function (DUF4355)
    pfam15227
    Location:15 → 58
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15822
    Location:289 → 493
    SPRY_PRY_TRIM5; PRY/SPRY domain in tripartite motif-binding protein 5 (TRIM5), also known as RING finger protein 88 (RNF88)

  2. NM_175677.4 → NP_783608.3  tripartite motif-containing 12C

    See identical proteins and their annotated locations for NP_783608.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC142110, AK050485, BU923784
    Consensus CDS
    CCDS52344.1
    UniProtKB/TrEMBL
    D3Z3L3, E9Q987, Q8CHU6
    Related
    ENSMUSP00000116775.3, ENSMUST00000130139.3
    Conserved Domains (4) summary
    smart00336
    Location:96 → 132
    BBOX; B-Box-type zinc finger
    pfam14265
    Location:164 → 234
    DUF4355; Domain of unknown function (DUF4355)
    pfam15227
    Location:15 → 58
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15822
    Location:289 → 493
    SPRY_PRY_TRIM5; PRY/SPRY domain in tripartite motif-binding protein 5 (TRIM5), also known as RING finger protein 88 (RNF88)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    103987961..104002649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153162.1 → XP_036009055.1  tripartite motif-containing 12C isoform X1

    UniProtKB/TrEMBL
    Q8CC73
    Conserved Domains (4) summary
    COG4372
    Location:119 → 308
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cd00162
    Location:15 → 58
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd19761
    Location:96 → 133
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
    cl17238
    Location:12 → 59
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein Strain
Heading Accession and Version

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