Cxxc4 CXXC finger 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cxxc4provided by MGI
Official Full Name: CXXC finger 4provided by MGI
Primary source: MGI:MGI:2442112
See related: Ensembl:ENSMUSG00000044365 AllianceGenome:MGI:2442112
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Idax; 9330210J02Rik; C030003J12Rik
Summary: Predicted to enable PDZ domain binding activity; methyl-CpG binding activity; and zinc ion binding activity. Acts upstream of or within Wnt signaling pathway. Located in cytoplasmic vesicle and nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; nervous system; and nose. Orthologous to human CXXC4 (CXXC finger protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in whole brain E14.5 (RPKM 3.9), CNS E18 (RPKM 3.3) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 62.12 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (133938927..133967924)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (134236144..134262163)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Idax and Rinf facilitate expression of Tet enzymes to promote neural and suppress trophectodermal programs during differentiation of embryonic stem cells.
Title: Idax and Rinf facilitate expression of Tet enzymes to promote neural and suppress trophectodermal programs during differentiation of embryonic stem cells.
CXXC4 mediates glucose-induced beta-cell proliferation.
Title: CXXC4 mediates glucose-induced β-cell proliferation.
IDAX depletion prevents TET2 downregulation in differentiating mouse embryonic stem cells
Title: Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables methyl-CpG binding	ISO Inferred from Sequence Orthology more info
enables methyl-CpG binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CXXC-type zinc finger protein 4

Names: inhibition of the Dvl and axin complex protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004367.4 → NP_001004367.2 CXXC-type zinc finger protein 4

Status: VALIDATED

Source sequence(s)

AC164408

Consensus CDS

CCDS17851.2

UniProtKB/TrEMBL

M0QWU0

Related

ENSMUSP00000138000.2, ENSMUST00000181904.3

Conserved Domains (1) summary

pfam02008
Location:300 → 340

zf-CXXC; CXXC zinc finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

133938927..133967924

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252642.2 → XP_030108502.1 CXXC-type zinc finger protein 4 isoform X2

UniProtKB/TrEMBL

M0QWU0

Conserved Domains (1) summary

pfam02008
Location:300 → 340

zf-CXXC; CXXC zinc finger domain
XM_006501561.4 → XP_006501624.1 CXXC-type zinc finger protein 4 isoform X1

See identical proteins and their annotated locations for XP_006501624.1

Conserved Domains (1) summary

pfam02008
Location:300 → 340

zf-CXXC; CXXC zinc finger domain
XM_006501568.4 → XP_006501631.1 CXXC-type zinc finger protein 4 isoform X3

Conserved Domains (1) summary

pfam02008
Location:300 → 340

zf-CXXC; CXXC zinc finger domain
XM_006501563.4 → XP_006501626.1 CXXC-type zinc finger protein 4 isoform X1

See identical proteins and their annotated locations for XP_006501626.1

Conserved Domains (1) summary

pfam02008
Location:300 → 340

zf-CXXC; CXXC zinc finger domain
XM_036163130.1 → XP_036019023.1 CXXC-type zinc finger protein 4 isoform X1

Conserved Domains (1) summary

pfam02008
Location:300 → 340

zf-CXXC; CXXC zinc finger domain
XM_006501566.5 → XP_006501629.1 CXXC-type zinc finger protein 4 isoform X1

See identical proteins and their annotated locations for XP_006501629.1

Conserved Domains (1) summary

pfam02008
Location:300 → 340

zf-CXXC; CXXC zinc finger domain
XM_006501564.4 → XP_006501627.1 CXXC-type zinc finger protein 4 isoform X1

See identical proteins and their annotated locations for XP_006501627.1

Conserved Domains (1) summary

pfam02008
Location:300 → 340

zf-CXXC; CXXC zinc finger domain