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Fam168a family with sequence similarity 168, member A [ Mus musculus (house mouse) ]

Gene ID: 319604, updated on 2-Nov-2024

Summary

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Official Symbol
Fam168aprovided by MGI
Official Full Name
family with sequence similarity 168, member Aprovided by MGI
Primary source
MGI:MGI:2442372
See related
Ensembl:ENSMUSG00000029461 AllianceGenome:MGI:2442372
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0280; 2610030B18Rik; B930006L02Rik
Summary
Predicted to be involved in positive regulation of base-excision repair. Orthologous to human FAM168A (family with sequence similarity 168 member A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 32.8), CNS E18 (RPKM 31.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fam168a in Genome Data Viewer
Location:
7 E2; 7 54.39 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100355594..100490853)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100706628..100841646)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family B (evectins) member 1 Neighboring gene predicted gene, 53385 Neighboring gene predicted gene, 35082 Neighboring gene STARR-seq mESC enhancer starr_19675 Neighboring gene STARR-seq mESC enhancer starr_19676 Neighboring gene STARR-seq mESC enhancer starr_19677 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2834 Neighboring gene RELT tumor necrosis factor receptor Neighboring gene STARR-positive B cell enhancer ABC_E4955 Neighboring gene Rho guanine nucleotide exchange factor 17 Neighboring gene microRNA 3102

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. Boon AC, et al. J Virol, 2009 Oct. PMID 19706712, Free PMC Article
  2. A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Kalsotra A, et al. Proc Natl Acad Sci U S A, 2008 Dec 23. PMID 19075228, Free PMC Article
  3. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in positive regulation of base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of base-excision repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of base-excision repair ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
protein FAM168A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362169.1 → NP_001349098.1  protein FAM168A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK043083, BC079886, CJ101582
    Consensus CDS
    CCDS90280.1
    UniProtKB/Swiss-Prot
    Q3UVC2, Q80U50, Q8BGN7, Q8BGZ2
    UniProtKB/TrEMBL
    A0A140LIJ1
    Related
    ENSMUSP00000102657.3, ENSMUST00000107042.9
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 244
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  2. NM_001362170.1 → NP_001349099.1  protein FAM168A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK048559, BC079886, CJ101582
    Consensus CDS
    CCDS21505.1
    UniProtKB/TrEMBL
    A0A140LIJ1, Q68FE1
    Related
    ENSMUSP00000146851.2, ENSMUST00000207875.2
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 235
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  3. NM_178764.4 → NP_848879.1  protein FAM168A isoform 2

    See identical proteins and their annotated locations for NP_848879.1

    Status: VALIDATED

    Source sequence(s)
    BC079886, CJ101582
    Consensus CDS
    CCDS21505.1
    UniProtKB/TrEMBL
    A0A140LIJ1, Q68FE1
    Related
    ENSMUSP00000038233.8, ENSMUST00000049053.9
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 235
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    100355594..100490853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153165.1 → XP_036009058.1  protein FAM168A isoform X4

    Conserved Domains (1) summary
    pfam14944
    Location:1 → 193
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  2. XM_006507920.3 → XP_006507983.1  protein FAM168A isoform X2

    See identical proteins and their annotated locations for XP_006507983.1

    UniProtKB/Swiss-Prot
    Q3UVC2, Q80U50, Q8BGN7, Q8BGZ2
    UniProtKB/TrEMBL
    A0A140LIJ1
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 244
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  3. XM_030242670.2 → XP_030098530.1  protein FAM168A isoform X1

    UniProtKB/TrEMBL
    A0A140LIJ1
    Conserved Domains (1) summary
    pfam14944
    Location:10 → 253
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  4. XM_036153164.1 → XP_036009057.1  protein FAM168A isoform X3

    UniProtKB/TrEMBL
    A0A140LIJ1
    Conserved Domains (1) summary
    pfam14944
    Location:10 → 244
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGZ2.1 GenPept UniProtKB/Swiss-Prot:Q8BGZ2

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