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Dcp1b decapping mRNA 1B [ Mus musculus (house mouse) ]

Gene ID: 319618, updated on 2-Nov-2024

Summary

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Official Symbol
Dcp1bprovided by MGI
Official Full Name
decapping mRNA 1Bprovided by MGI
Primary source
MGI:MGI:2442404
See related
Ensembl:ENSMUSG00000041477 AllianceGenome:MGI:2442404
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B930050E02Rik
Summary
Predicted to enable mRNA binding activity. Involved in cellular response to interleukin-17; protein localization to P-body; and protein localization to nucleus. Located in P-body. Is expressed in embryo. Orthologous to human DCP1B (decapping mRNA 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 25.1), thymus adult (RPKM 8.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Dcp1b in Genome Data Viewer
Location:
6 F1; 6 56.55 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (119152214..119198575)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (119175253..119221614)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, L type, alpha 1C subunit Neighboring gene predicted gene, 53338 Neighboring gene predicted gene, 50599 Neighboring gene STARR-seq mESC enhancer starr_17143 Neighboring gene STARR-positive B cell enhancer ABC_E10404 Neighboring gene calcium channel, voltage-dependent, alpha 2/delta subunit 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:119286263-119286553 Neighboring gene predicted gene, 52874 Neighboring gene leucine-rich repeats and transmembrane domains 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. mRNA decapping factor Dcp1a is essential for embryonic growth in mice. Ibayashi M, et al. Biochem Biophys Res Commun, 2021 May 28. PMID 33813271
  2. IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling. Herjan T, et al. Nat Immunol, 2018 Apr. PMID 29563620, Free PMC Article
  3. MicroRNA-23a promotes myelination in the central nervous system. Lin ST, et al. Proc Natl Acad Sci U S A, 2013 Oct 22. PMID 24101522, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to interleukin-17 IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
Inferred from Electronic Annotation
more info
  
involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to P-body IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mRNA-decapping enzyme 1B
Names
DCP1 decapping enzyme homolog B
NP_001028551.2
XP_006506301.1
XP_017177110.1
XP_017177111.1
XP_030111300.1
XP_030111301.1
XP_030111303.1
XP_036022105.1
XP_036022106.1
XP_036022107.1
XP_036022108.1
XP_036022109.1
XP_036022110.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033379.3 → NP_001028551.2  mRNA-decapping enzyme 1B

    See identical proteins and their annotated locations for NP_001028551.2

    Status: VALIDATED

    Source sequence(s)
    AC126453, AK047334, AK049193, AK053525
    Consensus CDS
    CCDS39610.1
    UniProtKB/Swiss-Prot
    B2RUI2, Q3U564, Q3V333
    UniProtKB/TrEMBL
    B9EIX0
    Related
    ENSMUSP00000108397.3, ENSMUST00000112777.9
    Conserved Domains (2) summary
    cd09804
    Location:16 → 131
    Dcp1; mRNA decapping enzyme 1 (Dcp1)
    pfam16741
    Location:536 → 575
    mRNA_decap_C; mRNA-decapping enzyme C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    119152214..119198575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506238.4 → XP_006506301.1  mRNA-decapping enzyme 1B isoform X1

    UniProtKB/Swiss-Prot
    B2RUI2, Q3U564, Q3V333
    Conserved Domains (2) summary
    cd09804
    Location:16 → 131
    Dcp1; mRNA decapping enzyme 1 (Dcp1)
    pfam16741
    Location:559 → 598
    mRNA_decap_C; mRNA-decapping enzyme C-terminus

  2. XM_030255443.1 → XP_030111303.1  mRNA-decapping enzyme 1B isoform X5

    Conserved Domains (1) summary
    pfam16741
    Location:375 → 414
    mRNA_decap_C; mRNA-decapping enzyme C-terminus

  3. XM_030255440.1 → XP_030111300.1  mRNA-decapping enzyme 1B isoform X4

    Conserved Domains (1) summary
    pfam16741
    Location:398 → 437
    mRNA_decap_C; mRNA-decapping enzyme C-terminus

  4. XM_017321622.2 → XP_017177111.1  mRNA-decapping enzyme 1B isoform X5

    Conserved Domains (1) summary
    pfam16741
    Location:375 → 414
    mRNA_decap_C; mRNA-decapping enzyme C-terminus

  5. XM_036166216.1 → XP_036022109.1  mRNA-decapping enzyme 1B isoform X5

    Conserved Domains (1) summary
    pfam16741
    Location:375 → 414
    mRNA_decap_C; mRNA-decapping enzyme C-terminus

  6. XM_030255441.1 → XP_030111301.1  mRNA-decapping enzyme 1B isoform X4

    Conserved Domains (1) summary
    pfam16741
    Location:398 → 437
    mRNA_decap_C; mRNA-decapping enzyme C-terminus

  7. XM_036166215.1 → XP_036022108.1  mRNA-decapping enzyme 1B isoform X5

    Conserved Domains (1) summary
    pfam16741
    Location:375 → 414
    mRNA_decap_C; mRNA-decapping enzyme C-terminus

  8. XM_036166212.1 → XP_036022105.1  mRNA-decapping enzyme 1B isoform X2

    Conserved Domains (1) summary
    pfam16741
    Location:433 → 472
    mRNA_decap_C; mRNA-decapping enzyme C-terminus

  9. XM_036166213.1 → XP_036022106.1  mRNA-decapping enzyme 1B isoform X3

    Conserved Domains (1) summary
    pfam16741
    Location:410 → 449
    mRNA_decap_C; mRNA-decapping enzyme C-terminus

  10. XM_036166217.1 → XP_036022110.1  mRNA-decapping enzyme 1B isoform X5

    Conserved Domains (1) summary
    pfam16741
    Location:375 → 414
    mRNA_decap_C; mRNA-decapping enzyme C-terminus

  11. XM_017321621.3 → XP_017177110.1  mRNA-decapping enzyme 1B isoform X2

    Conserved Domains (1) summary
    pfam16741
    Location:433 → 472
    mRNA_decap_C; mRNA-decapping enzyme C-terminus

  12. XM_036166214.1 → XP_036022107.1  mRNA-decapping enzyme 1B isoform X3

    Conserved Domains (1) summary
    pfam16741
    Location:410 → 449
    mRNA_decap_C; mRNA-decapping enzyme C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U564.1 GenPept UniProtKB/Swiss-Prot:Q3U564

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