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Eml5 echinoderm microtubule associated protein like 5 [ Mus musculus (house mouse) ]

Gene ID: 319670, updated on 2-Nov-2024

Summary

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Official Symbol
Eml5provided by MGI
Official Full Name
echinoderm microtubule associated protein like 5provided by MGI
Primary source
MGI:MGI:2442513
See related
Ensembl:ENSMUSG00000051166 AllianceGenome:MGI:2442513
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C130068M19Rik
Summary
Predicted to enable microtubule binding activity. Predicted to be located in cytoplasm and microtubule. Orthologous to human EML5 (EMAP like 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in frontal lobe adult (RPKM 12.3), cerebellum adult (RPKM 9.9) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Eml5 in Genome Data Viewer
Location:
12 E; 12 49.88 cM
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (98752863..98867770, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (98786604..98901511, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 7 Neighboring gene STARR-seq mESC enhancer starr_33000 Neighboring gene protein tyrosine phosphatase, non-receptor type 21 Neighboring gene STARR-positive B cell enhancer ABC_E9861 Neighboring gene zinc finger CCCH type containing 14 Neighboring gene predicted gene, 35463 Neighboring gene STARR-seq mESC enhancer starr_33001 Neighboring gene STARR-seq mESC enhancer starr_33002 Neighboring gene STARR-positive B cell enhancer ABC_E5348 Neighboring gene tetratricopeptide repeat domain 8 Neighboring gene STARR-seq mESC enhancer starr_33003 Neighboring gene predicted gene, 40554 Neighboring gene ribosomal protein L30, pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex. Schilling K, et al. Cerebellum, 2009 Dec. PMID 19554387
  2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
echinoderm microtubule-associated protein-like 5
Names
EMAP-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081191.1 → NP_001074660.1  echinoderm microtubule-associated protein-like 5

    See identical proteins and their annotated locations for NP_001074660.1

    Status: PROVISIONAL

    Source sequence(s)
    AC159193
    Consensus CDS
    CCDS36519.1
    UniProtKB/Swiss-Prot
    Q8BQM8, Q8BRL0, Q8R2W0
    UniProtKB/TrEMBL
    B2RY88
    Related
    ENSMUSP00000152709.2, ENSMUST00000223282.2
    Conserved Domains (4) summary
    COG2319
    Location:353 → 845
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:5 → 47
    HELP; HELP motif
    sd00039
    Location:64 → 104
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:725 → 1063
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    98752863..98867770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515972.4 → XP_006516035.1  echinoderm microtubule-associated protein-like 5 isoform X3

    UniProtKB/TrEMBL
    B2RY88
    Conserved Domains (4) summary
    COG2319
    Location:1387 → 1806
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:64 → 104
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:5 → 47
    HELP; HELP motif
    cl29593
    Location:725 → 1063
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_006515970.4 → XP_006516033.1  echinoderm microtubule-associated protein-like 5 isoform X1

    UniProtKB/TrEMBL
    B2RY88
    Conserved Domains (4) summary
    COG2319
    Location:1392 → 1811
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:64 → 104
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:5 → 47
    HELP; HELP motif
    cl29593
    Location:725 → 1063
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_036157493.1 → XP_036013386.1  echinoderm microtubule-associated protein-like 5 isoform X4

    UniProtKB/TrEMBL
    B2RY88
    Conserved Domains (4) summary
    COG2319
    Location:1461 → 1867
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:64 → 104
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:5 → 47
    HELP; HELP motif
    cl29593
    Location:725 → 1063
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_017315105.2 → XP_017170594.1  echinoderm microtubule-associated protein-like 5 isoform X2

    UniProtKB/TrEMBL
    B2RY88
    Conserved Domains (4) summary
    COG2319
    Location:1395 → 1806
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:64 → 104
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:5 → 47
    HELP; HELP motif
    cl29593
    Location:725 → 1063
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_030246770.1 → XP_030102630.1  echinoderm microtubule-associated protein-like 5 isoform X5

    UniProtKB/TrEMBL
    B2RY88
    Conserved Domains (4) summary
    COG2319
    Location:1153 → 1572
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:45 → 80
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:431 → 472
    HELP; HELP motif
    cl29593
    Location:483 → 821
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_006515976.2 → XP_006516039.1  echinoderm microtubule-associated protein-like 5 isoform X8

    Conserved Domains (4) summary
    COG2319
    Location:572 → 991
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:882 → 920
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:516 → 586
    HELP; HELP motif
    cl29593
    Location:72 → 317
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. XM_017315107.2 → XP_017170596.1  echinoderm microtubule-associated protein-like 5 isoform X6

    Conserved Domains (3) summary
    sd00039
    Location:64 → 104
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:5 → 47
    HELP; HELP motif
    cl29593
    Location:725 → 1063
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. XM_030246771.1 → XP_030102631.1  echinoderm microtubule-associated protein-like 5 isoform X7

    Conserved Domains (3) summary
    sd00039
    Location:64 → 104
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:5 → 47
    HELP; HELP motif
    cl29593
    Location:725 → 1063
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_004937514.1 RNA Sequence

  2. XR_004937513.1 RNA Sequence

  3. XR_001780456.2 RNA Sequence

  4. XR_004937508.1 RNA Sequence

  5. XR_001780453.2 RNA Sequence

  6. XR_003950056.1 RNA Sequence

  7. XR_004937516.1 RNA Sequence

  8. XR_004937510.1 RNA Sequence

  9. XR_004937509.1 RNA Sequence

  10. XR_003950058.1 RNA Sequence

  11. XR_004937512.1 RNA Sequence

  12. XR_004937511.1 RNA Sequence

  13. XR_001780457.2 RNA Sequence

  14. XR_001780455.2 RNA Sequence

  15. XR_003950059.2 RNA Sequence

  16. XR_004937515.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BQM8.2 GenPept UniProtKB/Swiss-Prot:Q8BQM8

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