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Tigar Trp53 induced glycolysis regulatory phosphatase [ Mus musculus (house mouse) ]

Gene ID: 319801, updated on 2-Nov-2024

Summary

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Official Symbol
Tigarprovided by MGI
Official Full Name
Trp53 induced glycolysis regulatory phosphataseprovided by MGI
Primary source
MGI:MGI:2442752
See related
Ensembl:ENSMUSG00000038028 AllianceGenome:MGI:2442752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9630033F20Rik
Summary
Enables fructose-2,6-bisphosphate 2-phosphatase activity. Involved in positive regulation of pentose-phosphate shunt and response to ischemia. Acts upstream of or within several processes, including fructose 2,6-bisphosphate metabolic process; negative regulation of catabolic process; and positive regulation of cardiac muscle cell apoptotic process. Located in mitochondrion. Is expressed in several structures, including brain; immune system; and liver. Orthologous to human TIGAR (TP53 induced glycolysis regulatory phosphatase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart adult (RPKM 8.1), cerebellum adult (RPKM 5.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tigar in Genome Data Viewer
Location:
6 F3; 6 61.92 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (127062079..127086564, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (127085116..127109552, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 6 Neighboring gene fibroblast growth factor 23 Neighboring gene STARR-seq mESC enhancer starr_17405 Neighboring gene STARR-positive B cell enhancer ABC_E2208 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:127059715-127059898 Neighboring gene STARR-seq mESC enhancer starr_17406 Neighboring gene cyclin D2 Neighboring gene RIKEN cDNA 9330179D12 gene Neighboring gene STARR-positive B cell enhancer ABC_E2805 Neighboring gene STARR-positive B cell enhancer ABC_E9676 Neighboring gene STARR-seq mESC enhancer starr_17407 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TIGAR plays neuroprotective roles in KA-induced excitotoxicity through reducing neuroinflammation and improving mitochondrial function. Huang SS, et al. Neurochem Int, 2022 Jan. PMID 34826530
  2. Ablation of cardiac TIGAR preserves myocardial energetics and cardiac function in the pressure overload heart failure model. Okawa Y, et al. Am J Physiol Heart Circ Physiol, 2019 Jun 1. PMID 30901275
  3. TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury. Zhang DM, et al. Free Radic Biol Med, 2019 Jun. PMID 30978385
  4. TIGAR regulates mitochondrial functions through SIRT1-PGC1α pathway and translocation of TIGAR into mitochondria in skeletal muscle. Geng J, et al. FASEB J, 2019 May. PMID 30726106
  5. Loss of TIGAR Induces Oxidative Stress and Meiotic Defects in Oocytes from Obese Mice. Wang H, et al. Mol Cell Proteomics, 2018 Jul. PMID 29776966, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TIGAR exacerbates obesity by triggering LRRK2-mediated defects in macroautophagy and chaperone-mediated autophagy in adipocytes.
    Title: TIGAR exacerbates obesity by triggering LRRK2-mediated defects in macroautophagy and chaperone-mediated autophagy in adipocytes.
  2. Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis.
    Title: Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis.
  3. Knockout of TIGAR enhances myocardial phosphofructokinase activity and preserves diastolic function in heart failure.
    Title: Knockout of TIGAR enhances myocardial phosphofructokinase activity and preserves diastolic function in heart failure.
  4. TIGAR alleviates oxidative stress in brain with extended ischemia via a pentose phosphate pathway-independent manner.
    Title: TIGAR alleviates oxidative stress in brain with extended ischemia via a pentose phosphate pathway-independent manner.
  5. The inhibition of TRIM35-mediated TIGAR ubiquitination enhances mitochondrial fusion and alleviates renal ischemia-reperfusion injury.
    Title: The inhibition of TRIM35-mediated TIGAR ubiquitination enhances mitochondrial fusion and alleviates renal ischemia-reperfusion injury.
  6. TIGAR deficiency enhances skeletal muscle thermogenesis by increasing neuromuscular junction cholinergic signaling.
    Title: TIGAR deficiency enhances skeletal muscle thermogenesis by increasing neuromuscular junction cholinergic signaling.
  7. TIGAR deficiency sensitizes angiotensin-II-induced renal fibrosis and glomerular injury.
    Title: TIGAR deficiency sensitizes angiotensin-II-induced renal fibrosis and glomerular injury.
  8. TIGAR plays neuroprotective roles in KA-induced excitotoxicity through reducing neuroinflammation and improving mitochondrial function.
    Title: TIGAR plays neuroprotective roles in KA-induced excitotoxicity through reducing neuroinflammation and improving mitochondrial function.
  9. Regulatory role of TIGAR on endothelial metabolism and angiogenesis.
    Title: Regulatory role of TIGAR on endothelial metabolism and angiogenesis.
  10. Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death.
    Title: Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (7)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fructose-2,6-bisphosphate 2-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructose-2,6-bisphosphate 2-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables fructose-2,6-bisphosphate 2-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables fructose-2,6-bisphosphate 2-phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to cobalt ion IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to cobalt ion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within fructose 2,6-bisphosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of glucose catabolic process to lactate via pyruvate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of glycolytic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within intestinal epithelial cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of mitophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of glucose catabolic process to lactate via pyruvate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of glycolytic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of kinase activity IC
Inferred by Curator
more info
 PubMed 
acts_upstream_of_or_within negative regulation of mitophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of programmed cell death ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hexokinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hexokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of pentose-phosphate shunt IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of pentose-phosphate shunt IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of pentose-phosphate shunt ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of response to DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of response to DNA damage checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to ischemia IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
fructose-2,6-bisphosphatase TIGAR
Names
TP53-induced glycolysis and apoptosis regulator
TP53-induced glycolysis regulatory phosphatase
Trp53 induced glycolysis repulatory phosphatase
probable fructose-2,6-bisphosphatase TIGAR
NP_795977.1
XP_006506317.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177003.5 → NP_795977.1  fructose-2,6-bisphosphatase TIGAR

    See identical proteins and their annotated locations for NP_795977.1

    Status: VALIDATED

    Source sequence(s)
    AC163683, AK145896
    Consensus CDS
    CCDS20563.1
    UniProtKB/Swiss-Prot
    Q8BZA9
    UniProtKB/TrEMBL
    B2RWB7
    Related
    ENSMUSP00000048643.9, ENSMUST00000039913.9
    Conserved Domains (1) summary
    pfam00300
    Location:6 → 241
    His_Phos_1; Histidine phosphatase superfamily (branch 1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    127062079..127086564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506254.2 → XP_006506317.1  fructose-2,6-bisphosphatase TIGAR isoform X1

    Conserved Domains (1) summary
    cl11399
    Location:1 → 163
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZA9.1 GenPept UniProtKB/Swiss-Prot:Q8BZA9

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