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Zcchc7 zinc finger, CCHC domain containing 7 [ Mus musculus (house mouse) ]

Gene ID: 319885, updated on 2-Nov-2024

Summary

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Official Symbol
Zcchc7provided by MGI
Official Full Name
zinc finger, CCHC domain containing 7provided by MGI
Primary source
MGI:MGI:2442912
See related
Ensembl:ENSMUSG00000035649 AllianceGenome:MGI:2442912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D4Wsu132e; 4930572I07Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in nuclear RNA surveillance. Predicted to be located in cytosol and nucleolus. Predicted to be part of TRAMP complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; extraembryonic component; sensory organ; and vibrissa. Orthologous to human ZCCHC7 (zinc finger CCHC-type containing 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bladder adult (RPKM 10.8), frontal lobe adult (RPKM 10.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Zcchc7 in Genome Data Viewer
Location:
4 B1; 4 23.57 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (44756556..44932215)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (44756558..44932215)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene paired box 5 Neighboring gene RIKEN cDNA 5730488B01 gene Neighboring gene Pax5 promoter region Neighboring gene Pax5 mhb enhancer Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:44769412-44769521 Neighboring gene aurora kinase C pseudogene Neighboring gene STARR-seq mESC enhancer starr_10082 Neighboring gene STARR-positive B cell enhancer mm9_chr4:44899270-44899570 Neighboring gene STARR-positive B cell enhancer mm9_chr4:44918473-44918774 Neighboring gene STARR-positive B cell enhancer ABC_E11237 Neighboring gene STARR-seq mESC enhancer starr_10084 Neighboring gene predicted gene 12678 Neighboring gene predicted gene, 30763

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
  2. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  3. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  5. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC62855

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in TRAMP-dependent tRNA surveillance pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in nuclear mRNA surveillance of mRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear polyadenylation-dependent CUT catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear polyadenylation-dependent snRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear polyadenylation-dependent snoRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of TRAMP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger CCHC domain-containing protein 7
Names
TRAMP-like complex RNA-binding factor ZCCHC7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138590.4 → NP_613056.2  zinc finger CCHC domain-containing protein 7

    See identical proteins and their annotated locations for NP_613056.2

    Status: VALIDATED

    Source sequence(s)
    AA277854, AL805896, CF732773, CJ150974, CJ155194
    Consensus CDS
    CCDS18127.2
    UniProtKB/Swiss-Prot
    B1AX39, Q3TZN5, Q8C915, Q9CYZ9
    Related
    ENSMUSP00000103454.3, ENSMUST00000107824.9
    Conserved Domains (1) summary
    COG5082
    Location:233 → 362
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    44756556..44932215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537985.4 → XP_006538048.1  zinc finger CCHC domain-containing protein 7 isoform X2

    Conserved Domains (1) summary
    COG5082
    Location:233 → 362
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  2. XM_006537984.5 → XP_006538047.1  zinc finger CCHC domain-containing protein 7 isoform X1

    See identical proteins and their annotated locations for XP_006538047.1

    UniProtKB/Swiss-Prot
    B1AX39, Q3TZN5, Q8C915, Q9CYZ9
    Conserved Domains (1) summary
    COG5082
    Location:233 → 362
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

  3. XM_006537986.4 → XP_006538049.1  zinc finger CCHC domain-containing protein 7 isoform X3

    Conserved Domains (1) summary
    COG5082
    Location:86 → 215
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

RNA

  1. XR_004941921.1 RNA Sequence

  2. XR_003954962.2 RNA Sequence

  3. XR_003954965.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177027.3: Suppressed sequence

    Description
    NM_177027.3: This RefSeq was permanently suppressed because the transcript was incompletely processed at the 3' end.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1AX39.1 GenPept UniProtKB/Swiss-Prot:B1AX39

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