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Golm2 golgi membrane protein 2 [ Mus musculus (house mouse) ]

Gene ID: 319996, updated on 2-Nov-2024

Summary

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Official Symbol
Golm2provided by MGI
Official Full Name
golgi membrane protein 2provided by MGI
Primary source
MGI:MGI:2443129
See related
Ensembl:ENSMUSG00000060227 AllianceGenome:MGI:2443129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Casc4; VGFG2573; D130060C09Rik
Summary
Predicted to be located in Golgi apparatus. Is expressed in genitourinary system. Orthologous to human GOLM2 (golgi membrane protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 11.0), frontal lobe adult (RPKM 9.7) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Golm2 in Genome Data Viewer
Location:
2 E5; 2 60.43 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121696255..121766701)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121866970..121936220)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene FERM domain containing 5 Neighboring gene septin 2 pseudogene Neighboring gene ribosomal protein S4, X-linked pseudogene Neighboring gene STARR-seq mESC enhancer starr_05538 Neighboring gene STARR-seq mESC enhancer starr_05541 Neighboring gene STARR-seq mESC enhancer starr_05542 Neighboring gene STARR-seq mESC enhancer starr_05544 Neighboring gene STARR-seq mESC enhancer starr_05545 Neighboring gene predicted gene, 39916 Neighboring gene CTD small phosphatase like 2 Neighboring gene MAGE family member B3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  2. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein GOLM2
Names
cancer susceptibility candidate 4
cancer susceptibility candidate gene 4 protein homolog
protein CASC4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205369.1 → NP_001192298.1  protein GOLM2 isoform 3

    See identical proteins and their annotated locations for NP_001192298.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (3) is longer than isoform 1.
    Source sequence(s)
    AL845286, BC064446
    Consensus CDS
    CCDS57183.1
    UniProtKB/Swiss-Prot
    A2AR57, Q6P2L7, Q6RZW5, Q6RZW6, Q8C4Z2
    Related
    ENSMUSP00000077811.4, ENSMUST00000078752.10
    Conserved Domains (1) summary
    cl19219
    Location:118 → 200
    DUF342; Protein of unknown function (DUF342)

  2. NM_001205370.1 → NP_001192299.1  protein GOLM2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon but includes a different in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AL845286
    Consensus CDS
    CCDS57184.1
    UniProtKB/TrEMBL
    E9PZJ6
    Related
    ENSMUSP00000106216.4, ENSMUST00000110586.10
    Conserved Domains (1) summary
    cl19219
    Location:118 → 200
    DUF342; Protein of unknown function (DUF342)

  3. NM_001205371.1 → NP_001192300.1  protein GOLM2 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, and contains an alternate in-frame coding exon, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AK131751, AL845286
    UniProtKB/TrEMBL
    A2AR60
    Related
    ENSMUSP00000117883.2, ENSMUST00000136023.2
    Conserved Domains (1) summary
    cl19219
    Location:2 → 81
    DUF342; Protein of unknown function (DUF342)

  4. NM_177054.5 → NP_796028.2  protein GOLM2 isoform 1

    See identical proteins and their annotated locations for NP_796028.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AY484583, BC064446, BP765295
    Consensus CDS
    CCDS16650.1
    UniProtKB/Swiss-Prot
    Q6P2L7
    Related
    ENSMUSP00000087357.6, ENSMUST00000089912.12
    Conserved Domains (1) summary
    cl19219
    Location:118 → 200
    DUF342; Protein of unknown function (DUF342)

  5. NM_199038.3 → NP_950239.2  protein GOLM2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AI848011, AK080364, AY484583, BC064446, BP765295
    Consensus CDS
    CCDS50686.1
    UniProtKB/Swiss-Prot
    Q6P2L7
    Related
    ENSMUSP00000087360.4, ENSMUST00000089915.10
    Conserved Domains (1) summary
    cl19219
    Location:118 → 200
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    121696255..121766701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162294.1 → XP_036018187.1  protein GOLM2 isoform X1

    Conserved Domains (1) summary
    TIGR02168
    Location:42 → 195
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_036162295.1 → XP_036018188.1  protein GOLM2 isoform X2

    Conserved Domains (1) summary
    TIGR02168
    Location:42 → 195
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P2L7.1 GenPept UniProtKB/Swiss-Prot:Q6P2L7

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