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Fstl4 follistatin-like 4 [ Mus musculus (house mouse) ]

Gene ID: 320027, updated on 2-Nov-2024

Summary

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Official Symbol
Fstl4provided by MGI
Official Full Name
follistatin-like 4provided by MGI
Primary source
MGI:MGI:2443199
See related
Ensembl:ENSMUSG00000036264 AllianceGenome:MGI:2443199
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SPIG1; mKIAA1061; B230374F23Rik
Summary
Enables brain-derived neurotrophic factor binding activity. Acts upstream of or within negative regulation of brain-derived neurotrophic factor receptor signaling pathway; negative regulation of collateral sprouting; and negative regulation of dendritic spine development. Located in secretory granule. Is expressed in medulla oblongata basal plate mantle layer; neural retina; olfactory cortex mantle layer; pons mantle layer; and telencephalon mantle layer. Orthologous to human FSTL4 (follistatin like 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in frontal lobe adult (RPKM 3.4), cortex adult (RPKM 3.3) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Fstl4 in Genome Data Viewer
Location:
11 B1.3; 11 31.86 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (52655320..53083277)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (52764489..53192450)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29466 Neighboring gene predicted gene, 30366 Neighboring gene STARR-seq mESC enhancer starr_29468 Neighboring gene predicted gene, 39823 Neighboring gene VISTA enhancer mm1724 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52800603-52800790 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52942269-52942487 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52946269-52946452 Neighboring gene predicted gene 11186 Neighboring gene STARR-seq mESC enhancer starr_29473 Neighboring gene STARR-seq mESC enhancer starr_29474 Neighboring gene TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_29475 Neighboring gene STARR-seq mESC enhancer starr_29476 Neighboring gene STARR-positive B cell enhancer ABC_E2987 Neighboring gene heat shock protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Enhanced extinction of aversive memories in mice lacking SPARC-related protein containing immunoglobulin domains 1 (SPIG1/FSTL4). Suzuki R, et al. Neurobiol Learn Mem, 2018 Jul. PMID 29783061
  2. Identification of retinal ganglion cells and their projections involved in central transmission of information about upward and downward image motion. Yonehara K, et al. PLoS One, 2009. PMID 19177171, Free PMC Article
  3. Expression of SPIG1 reveals development of a retinal ganglion cell subtype projecting to the medial terminal nucleus in the mouse. Yonehara K, et al. PLoS One, 2008 Feb 6. PMID 18253481, Free PMC Article
  4. Receptive Field Sizes of Nyx(nob) Mouse Retinal Ganglion Cells. Hölzel MB, et al. Int J Mol Sci, 2022 Mar 16. PMID 35328623, Free PMC Article
  5. Nystagmus in patients with congenital stationary night blindness (CSNB) originates from synchronously firing retinal ganglion cells. Winkelman BHJ, et al. PLoS Biol, 2019 Sep. PMID 31513577, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study showed enhanced extinction of aversive memories in mice lacking SPARC-related protein containing immunoglobulin domains 1 (SPIG1/FSTL4).
    Title: Enhanced extinction of aversive memories in mice lacking SPARC-related protein containing immunoglobulin domains 1 (SPIG1/FSTL4).
  2. This study demonistrated that SPIG1 negatively regulates BDNF maturation.
    Title: SPIG1 negatively regulates BDNF maturation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

General gene information

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Markers

Homology

Clone Names

  • KIAA1061

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables brain-derived neurotrophic factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT acts_upstream_of_or_within negative regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of brain-derived neurotrophic factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of collateral sprouting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of dendritic spine development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of collateral sprouting IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in secretory granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
follistatin-related protein 4
Names
follistatin-like protein 4
m-D/Bsp120I 1-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177059.4 → NP_796033.2  follistatin-related protein 4 precursor

    See identical proteins and their annotated locations for NP_796033.2

    Status: VALIDATED

    Source sequence(s)
    AL596382, AL604002, AL662836, AL662855
    Consensus CDS
    CCDS24673.1
    UniProtKB/Swiss-Prot
    A2RT35, Q5DU03, Q5STE3
    Related
    ENSMUSP00000042007.8, ENSMUST00000036796.8
    Conserved Domains (7) summary
    cd00096
    Location:266 → 322
    Ig; Immunoglobulin domain
    cd05736
    Location:357 → 432
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins
    smart00410
    Location:255 → 322
    IG_like; Immunoglobulin like
    cd00104
    Location:92 → 132
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam07679
    Location:340 → 429
    I-set; Immunoglobulin I-set domain
    pfam13499
    Location:178 → 241
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:178 → 242
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    52655320..53083277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533539.5 → XP_006533602.1  follistatin-related protein 4 isoform X1

    Conserved Domains (1) summary
    cl11960
    Location:1 → 55
    Ig; Immunoglobulin domain

RNA

  1. XR_388477.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5STE3.1 GenPept UniProtKB/Swiss-Prot:Q5STE3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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