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Olfml2b olfactomedin-like 2B [ Mus musculus (house mouse) ]

Gene ID: 320078, updated on 28-Oct-2024

Summary

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Official Symbol
Olfml2bprovided by MGI
Official Full Name
olfactomedin-like 2Bprovided by MGI
Primary source
MGI:MGI:2443310
See related
Ensembl:ENSMUSG00000038463 AllianceGenome:MGI:2443310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110018N05Rik; 4832415H08Rik
Summary
Enables extracellular matrix binding activity and identical protein binding activity. Acts upstream of or within extracellular matrix organization. Located in extracellular matrix. Is expressed in several structures, including alimentary system; limb; nervous system; neural retina; and skeleton. Orthologous to human OLFML2B (olfactomedin like 2B). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in limb E14.5 (RPKM 18.2), mammary gland adult (RPKM 16.3) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Olfml2b in Genome Data Viewer
Location:
1 H3; 1 76.95 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170472101..170510356)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (170644431..170682789)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene nitric oxide synthase 1 (neuronal) adaptor protein Neighboring gene predicted gene, 46171 Neighboring gene STARR-seq mESC enhancer starr_02995 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene activating transcription factor 6 Neighboring gene predicted gene, 23523 Neighboring gene predicted gene, 25235

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterization of photomedins: novel olfactomedin-domain-containing proteins with chondroitin sulphate-E-binding activity. Furutani Y, et al. Biochem J, 2005 Aug 1. PMID 15836428, Free PMC Article
  2. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article
  3. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Abonnenc M, et al. Circ Res, 2013 Oct 25. PMID 24006456
  4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within extracellular matrix organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
olfactomedin-like protein 2B
Names
photomedin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404301.1 → NP_001391230.1  olfactomedin-like protein 2B isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC125021

  2. NM_001404302.1 → NP_001391231.1  olfactomedin-like protein 2B isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC125021

  3. NM_001404304.1 → NP_001391233.1  olfactomedin-like protein 2B isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC125021

  4. NM_001404305.1 → NP_001391234.1  olfactomedin-like protein 2B isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC125021

  5. NM_001404306.1 → NP_001391235.1  olfactomedin-like protein 2B isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC125021

  6. NM_001404307.1 → NP_001391236.1  olfactomedin-like protein 2B isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC125021

  7. NM_001404308.1 → NP_001391237.1  olfactomedin-like protein 2B isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    AC125021

  8. NM_001404309.1 → NP_001391238.1  olfactomedin-like protein 2B isoform 9 precursor

    Status: VALIDATED

    Source sequence(s)
    AC125021

  9. NM_001404310.1 → NP_001391239.1  olfactomedin-like protein 2B isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC125021

  10. NM_001404311.1 → NP_001391240.1  olfactomedin-like protein 2B isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC125021

  11. NM_177068.5 → NP_796042.3  olfactomedin-like protein 2B isoform 3 precursor

    See identical proteins and their annotated locations for NP_796042.3

    Status: VALIDATED

    Source sequence(s)
    AC125021
    Consensus CDS
    CCDS15473.1
    UniProtKB/Swiss-Prot
    Q3T9I5, Q3V1G4, Q8C106, Q8R3B2
    Related
    ENSMUSP00000047291.9, ENSMUST00000046792.9
    Conserved Domains (2) summary
    pfam02191
    Location:494 → 742
    OLF; Olfactomedin-like domain
    pfam05377
    Location:176 → 202
    FlaC_arch; Flagella accessory protein C (FlaC)

RNA

  1. NR_175831.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125021

  2. NR_175832.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125021

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    170472101..170510356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V1G4.2 GenPept UniProtKB/Swiss-Prot:Q3V1G4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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