U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lipi lipase, member I [ Mus musculus (house mouse) ]

Gene ID: 320355, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Lipiprovided by MGI
Official Full Name
lipase, member Iprovided by MGI
Primary source
MGI:MGI:2443868
See related
Ensembl:ENSMUSG00000032948 AllianceGenome:MGI:2443868
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
lpd1; D930038D03Rik
Summary
Predicted to enable heparin binding activity and phospholipase activity. Predicted to be involved in lipid catabolic process. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Is expressed in mandible and maxilla. Orthologous to human LIPI (lipase I). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward genital fat pad adult (RPKM 1.9) See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Lipi in Genome Data Viewer
Location:
16 C3.1; 16 43.22 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (75337431..75382960, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (75540514..75586072, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene roundabout guidance receptor 2 Neighboring gene STARR-seq mESC enhancer starr_41263 Neighboring gene STARR-seq mESC enhancer starr_41264 Neighboring gene predicted gene, 52278 Neighboring gene STARR-seq mESC enhancer starr_41265 Neighboring gene STARR-seq mESC enhancer starr_41266 Neighboring gene STARR-seq mESC enhancer starr_41267 Neighboring gene nuclear encoded tRNA isoleucine 1 (anticodon AAT) Neighboring gene STARR-seq mESC enhancer starr_41269 Neighboring gene RNA binding motif protein 11 Neighboring gene predicted gene, 41474 Neighboring gene predicted gene, 30162

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans. Wen XY, et al. Hum Mol Genet, 2003 May 15. PMID 12719377
  2. Characterization of lpd (lipid defect): a novel mutation on mouse chromosome 16 associated with a defect in triglyceride metabolism. Wen XY, et al. Hum Mol Genet, 1998 Apr. PMID 9499429
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
lipase member I
NP_001239442.1
XP_011244435.1
XP_011244436.1
XP_011244437.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252513.2 → NP_001239442.1  lipase member I

    See identical proteins and their annotated locations for NP_001239442.1

    Status: VALIDATED

    Source sequence(s)
    AC129186, AC166995
    Consensus CDS
    CCDS28272.2
    UniProtKB/TrEMBL
    F6YQT7
    Related
    ENSMUSP00000053447.11, ENSMUST00000062721.11
    Conserved Domains (1) summary
    cd00707
    Location:57 → 346
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    75337431..75382960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246134.1 → XP_011244436.1  lipase member I isoform X2

    Conserved Domains (1) summary
    cd00707
    Location:57 → 346
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

  2. XM_011246135.1 → XP_011244437.1  lipase member I isoform X3

    Conserved Domains (1) summary
    cd00707
    Location:41 → 330
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

  3. XM_011246133.1 → XP_011244435.1  lipase member I isoform X1

    Conserved Domains (1) summary
    cd00707
    Location:57 → 346
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177142.4: Suppressed sequence

    Description
    NM_177142.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous