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Itpkb inositol 1,4,5-trisphosphate 3-kinase B [ Mus musculus (house mouse) ]

Gene ID: 320404, updated on 8-Sep-2024

Summary

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Official Symbol
Itpkbprovided by MGI
Official Full Name
inositol 1,4,5-trisphosphate 3-kinase Bprovided by MGI
Primary source
MGI:MGI:109235
See related
Ensembl:ENSMUSG00000038855 AllianceGenome:MGI:109235
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110033J02Rik; E130307H12Rik
Summary
Enables inositol-1,4,5-trisphosphate 3-kinase activity. Acts upstream of or within several processes, including common myeloid progenitor cell proliferation; negative regulation of neutrophil apoptotic process; and regulation of hemopoiesis. Located in cytosol; membrane; and nucleus. Is expressed in alimentary system; facial bone primordium; liver; nervous system; and urinary system. Orthologous to human ITPKB (inositol-trisphosphate 3-kinase B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 21.8), thymus adult (RPKM 19.8) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Itpkb in Genome Data Viewer
Location:
1 H4; 1 84.27 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (180156655..180252367)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (180330390..180424802)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5867 Neighboring gene presenilin 2 Neighboring gene STARR-positive B cell enhancer ABC_E5868 Neighboring gene predicted gene, 31728 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:182226418-182226527 Neighboring gene predicted gene, 39713 Neighboring gene STARR-positive B cell enhancer ABC_E3341 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:182286358-182286687 Neighboring gene STARR-positive B cell enhancer ABC_E2591 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:182296519-182296775 Neighboring gene STARR-positive B cell enhancer ABC_E1575 Neighboring gene STARR-positive B cell enhancer mm9_chr1:182331940-182332241 Neighboring gene STARR-positive B cell enhancer ABC_E5870 Neighboring gene predicted gene, 39712 Neighboring gene STARR-positive B cell enhancer ABC_E5871 Neighboring gene mechanosensory transduction mediator Neighboring gene STARR-positive B cell enhancer ABC_E5872 Neighboring gene STARR-positive B cell enhancer mm9_chr1:182471419-182471720 Neighboring gene STARR-positive B cell enhancer ABC_E3342 Neighboring gene predicted gene, 31986

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca(2+) mobilization and the inflammatory activity of dendritic cells. Marongiu L, et al. Sci Signal, 2021 Mar 30. PMID 33785611, Free PMC Article
  2. The Parkinson's disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release. Apicco DJ, et al. Proc Natl Acad Sci U S A, 2021 Jan 5. PMID 33443159, Free PMC Article
  3. Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease. Thangavelu G, et al. Blood, 2020 Jan 2. PMID 31697815, Free PMC Article
  4. Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease. Miller AT, et al. PLoS One, 2015. PMID 26121493, Free PMC Article
  5. IP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice. Siegemund S, et al. Blood, 2015 Apr 30. PMID 25788703, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca(2+) mobilization and the inflammatory activity of dendritic cells.
    Title: Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca(2+) mobilization and the inflammatory activity of dendritic cells.
  2. The Parkinson's disease-associated gene ITPKB protects against alpha-synuclein aggregation by regulating ER-to-mitochondria calcium release.
    Title: The Parkinson's disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release.
  3. Thus, non-canonical phosphoinositide 3-kinase-antagonism by Itpkb restricts pre-T cell receptor induced metabolic activation to enforce coincidence-detection of pre-T cell receptor expression and Notch-engagement.
    Title: Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent.
  4. These data identify Itpkb as an essential mediator of T cell activation and suggest Itpkb inhibition as a novel approach to treat autoimmune disease.
    Title: Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease.
  5. Itpkb controls hematopoietic stem cell homeostasis and prevent death from severe anemia in mice.
    Title: IP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice.
  6. Itpkb controls survival, proliferation and cytokine production in mouse peripheral T cells.
    Title: Inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) controls survival, proliferation and cytokine production in mouse peripheral T cells.
  7. controls survival and prevents anergy in B cells
    Title: Inositol 1,4,5-trisphosphate 3-kinase B controls survival and prevents anergy in B cells.
  8. These data show that the absence of expression of the three isoenzymes of Itpk does not prevent the formation of IP5 and IP6, at least in mouse embryonic fibroblasts.[Itpka, Itpkb, Itpkc]
    Title: The absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate in mouse embryonic fibroblasts.
  9. B cells from Itpkb(-/-) Ig hen egg lysozyme mice possess an anergic phenotype, hypoproliferate in response to cognate Ag, and yet they exhibit enhanced Ag-induced calcium signaling
    Title: Inositol 1,4,5-trisphosphate 3-kinase B is a negative regulator of BCR signaling that controls B cell selection and tolerance induction.
  10. InsP3KB is also a physiological modulator of myelopoiesis.
    Title: Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables inositol tetrakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol-1,4,5-trisphosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol-1,4,5-trisphosphate 3-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-1,4,5-trisphosphate 3-kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables inositol-1,4,5-trisphosphate 3-kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell surface receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within common myeloid progenitor cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inositol trisphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within myeloid cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neutrophil apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
inositol-trisphosphate 3-kinase B
NP_001074644.1
NP_001405214.1
NP_001405215.1
XP_006496965.1
XP_030110829.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081175.2 → NP_001074644.1  inositol-trisphosphate 3-kinase B isoform a

    See identical proteins and their annotated locations for NP_001074644.1

    Status: VALIDATED

    Source sequence(s)
    AC121838
    Consensus CDS
    CCDS35808.1
    UniProtKB/TrEMBL
    B2RXC2
    Related
    ENSMUSP00000069851.7, ENSMUST00000070181.7
    Conserved Domains (2) summary
    PHA03307
    Location:24 → 317
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam03770
    Location:722 → 933
    IPK; Inositol polyphosphate kinase

  2. NM_001418285.1 → NP_001405214.1  inositol-trisphosphate 3-kinase B isoform a

    Status: VALIDATED

    Source sequence(s)
    AC121838
    UniProtKB/TrEMBL
    B2RXC2

  3. NM_001418286.1 → NP_001405215.1  inositol-trisphosphate 3-kinase B isoform b

    Status: VALIDATED

    Source sequence(s)
    AC121838

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    180156655..180252367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496902.5 → XP_006496965.1  inositol-trisphosphate 3-kinase B isoform X2

    UniProtKB/TrEMBL
    Q8BKB2

  2. XM_030254969.2 → XP_030110829.1  inositol-trisphosphate 3-kinase B isoform X1

    UniProtKB/TrEMBL
    B2RXC2
    Conserved Domains (2) summary
    PHA03307
    Location:24 → 317
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam03770
    Location:722 → 933
    IPK; Inositol polyphosphate kinase
Nucleotide Protein Strain
Heading Accession and Version

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