Nron non-protein coding RNA, repressor of NFAT [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nronprovided by MGI
Official Full Name: non-protein coding RNA, repressor of NFATprovided by MGI
Primary source: MGI:MGI:2444126
See related: Ensembl:ENSMUSG00000086484 AllianceGenome:MGI:2444126
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm24353; A630071L07Rik
Summary: Acts upstream of or within negative regulation of dephosphorylation; regulation of calcineurin-NFAT signaling cascade; and regulation of cytokine production. Part of ribonucleoprotein complex. Is expressed in several structures, including gonad; heart; immune system; liver; and lung. Orthologous to human NRON (non-coding repressor of NFAT). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thymus adult (RPKM 2.6), whole brain E14.5 (RPKM 0.1) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 22.53 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (33695828..33703603)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (33805816..33813591)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of NRON and TUG1 long noncoding RNAs in inflammation and the pathogenesis of EAE.
Title: Involvement of NRON and TUG1 long noncoding RNAs in inflammation and the pathogenesis of EAE.
LncRNA NRON promotes tumorigenesis by enhancing MDM2 activity toward tumor suppressor substrates.
Title: LncRNA NRON promotes tumorigenesis by enhancing MDM2 activity toward tumor suppressor substrates.
LncRNA Nron Inhibits Bone Resorption in Periodontitis.
Title: LncRNA Nron Inhibits Bone Resorption in Periodontitis.
A functional motif of long noncoding RNA Nron against osteoporosis.
Title: A functional motif of long noncoding RNA Nron against osteoporosis.
LncRNA NRON alleviates atrial fibrosis through suppression of M1 macrophages activated by atrial myocytes.
Title: LncRNA NRON alleviates atrial fibrosis through suppression of M1 macrophages activated by atrial myocytes.
data indicated that NRON alleviates atrial fibrosis via promoting NFATc3 phosphorylation.
Title: LncRNA NRON alleviates atrial fibrosis via promoting NFATc3 phosphorylation.
Identification of a noncoding RNA repressor of the nuclear factor of activated T cells (NFAT) activity.
Title: A strategy for probing the function of noncoding RNAs finds a repressor of NFAT.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

Nron (e-PCR), detects polymorphism
- UniSTS:547559

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of dephosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of calcineurin-NFAT signaling cascade	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.