U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pgap3 post-GPI attachment to proteins 3 [ Mus musculus (house mouse) ]

Gene ID: 320655, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Pgap3provided by MGI
Official Full Name
post-GPI attachment to proteins 3provided by MGI
Primary source
MGI:MGI:2444461
See related
Ensembl:ENSMUSG00000038208 AllianceGenome:MGI:2444461
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CAB2; Perld1; D430035D22Rik
Summary
Predicted to enable hydrolase activity, acting on ester bonds. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 4. Orthologous to human PGAP3 (post-GPI attachment to proteins phospholipase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in colon adult (RPKM 24.1), duodenum adult (RPKM 23.9) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Pgap3 in Genome Data Viewer
Location:
11 D; 11 61.75 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98279498..98292022, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98388672..98401196, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene titin-cap Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98254740-98254849 Neighboring gene phenylethanolamine-N-methyltransferase Neighboring gene STARR-seq mESC enhancer starr_30667 Neighboring gene erb-b2 receptor tyrosine kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E5275 Neighboring gene migration and invasion enhancer 1 Neighboring gene growth factor receptor bound protein 7

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Significance of glycosylphosphatidylinositol-anchored protein enrichment in lipid rafts for the control of autoimmunity. Wang Y, et al. J Biol Chem, 2013 Aug 30. PMID 23864655, Free PMC Article
  2. Enhanced response of T lymphocytes from Pgap3 knockout mouse: Insight into roles of fatty acid remodeling of GPI anchored proteins. Murakami H, et al. Biochem Biophys Res Commun, 2012 Jan 27. PMID 22227195
  3. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity, acting on ester bonds IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity, acting on ester bonds ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity, acting on ester bonds ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GPI anchor metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GPI anchor metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
post-GPI attachment to proteins factor 3
Names
PER1-like domain-containing protein 1
per1-like domain containing 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033537.2 → NP_001028709.2  post-GPI attachment to proteins factor 3 precursor

    See identical proteins and their annotated locations for NP_001028709.2

    Status: VALIDATED

    Source sequence(s)
    AL591390
    Consensus CDS
    CCDS25348.1
    UniProtKB/Swiss-Prot
    A2A558, A2A559, Q3TCA8
    Related
    ENSMUSP00000088337.6, ENSMUST00000090827.12
    Conserved Domains (1) summary
    pfam04080
    Location:54 → 306
    Per1; Per1-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    98279498..98292022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533549.4 → XP_006533612.1  post-GPI attachment to proteins factor 3 isoform X1

    UniProtKB/Swiss-Prot
    A2A559
    Related
    ENSMUSP00000119668.2, ENSMUST00000128897.2
    Conserved Domains (1) summary
    pfam04080
    Location:54 → 255
    Per1; Per1-like family

  2. XM_006533550.5 → XP_006533613.1  post-GPI attachment to proteins factor 3 isoform X2

    Conserved Domains (1) summary
    pfam04080
    Location:1 → 234
    Per1; Per1-like family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A559.1 GenPept UniProtKB/Swiss-Prot:A2A559

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools