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Prdx6b peroxiredoxin 6B [ Mus musculus (house mouse) ]

Gene ID: 320769, updated on 2-Nov-2024

Summary

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Official Symbol
Prdx6bprovided by MGI
Official Full Name
peroxiredoxin 6Bprovided by MGI
Primary source
MGI:MGI:1336888
See related
Ensembl:ENSMUSG00000050114 AllianceGenome:MGI:1336888
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aop2-rs1; Prdx5-rs1; Prdx6-ps1; Prdx6-rs1; 1-cysPrx-P1; Prdx6-rs1-ps; 4930414C22Rik
Summary
This intronless gene is similar to the multi-exon peroxiredoxin 6 gene located on chromosome 1. It is transcribed and the ORF is intact compared to that of the peroxiredoxin 6 gene. This gene could be considered a transcribed pseudogene based on a failure to detect the protein in vivo in PMID:14644414. However, NCBI is representing the protein due to mass spectrometry data in PMID:18614015, which detected at least one peptide that is specific for this protein. [provided by RefSeq, Mar 2011]
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Genomic context

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See Prdx6b in Genome Data Viewer
Location:
2 C3; 2 48.03 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (80122814..80125702)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (80292470..80295358)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 1A, calmodulin-dependent Neighboring gene STARR-seq mESC enhancer starr_04943 Neighboring gene predicted gene 13674 Neighboring gene STARR-positive B cell enhancer ABC_E5939 Neighboring gene predicted gene, 36153 Neighboring gene baculoviral IAP repeat-containing 2 pseudogene Neighboring gene DnaJ heat shock protein family (Hsp40) member C10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. 1-Cys peroxiredoxin knock-out mice express mRNA but not protein for a highly related intronless gene. Mo Y, et al. FEBS Lett, 2003 Dec 4. PMID 14644414
  2. Characterization of the murine gene encoding Aop2 (antioxidant protein 2) and identification of two highly related genes. Phelan SA, et al. Genomics, 1998 Nov 15. PMID 9806838
  3. Genetic mapping of six mouse peroxiredoxin genes and fourteen peroxiredoxin related sequences. Lyu MS, et al. Mamm Genome, 1999 Oct. PMID 10501973
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC107184

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-acylglycerophosphocholine O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium-independent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular oxidant detoxification ISO
Inferred from Sequence Orthology
more info
  
involved_in glycerophospholipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxiredoxin 6, related sequence 1
Names
anti-oxidant protein 2 related sequence 1
peroxiredoxin 5 related sequence 1
peroxiredoxin 6, pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177256.5 → NP_796230.1  peroxiredoxin 6, related sequence 1

    See identical proteins and their annotated locations for NP_796230.1

    Status: VALIDATED

    Source sequence(s)
    AK161395, AL928587
    Consensus CDS
    CCDS38158.1
    UniProtKB/TrEMBL
    Q8BG37
    Related
    ENSMUSP00000133276.3, ENSMUST00000057072.6
    Conserved Domains (2) summary
    COG0450
    Location:5 → 199
    AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
    cd03016
    Location:7 → 222
    PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    80122814..80125702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_033713.1: Suppressed sequence

    Description
    NR_033713.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version

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