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Gfm2 G elongation factor, mitochondrial 2 [ Mus musculus (house mouse) ]

Gene ID: 320806, updated on 3-Nov-2024

Summary

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Official Symbol
Gfm2provided by MGI
Official Full Name
G elongation factor, mitochondrial 2provided by MGI
Primary source
MGI:MGI:2444783
See related
Ensembl:ENSMUSG00000021666 AllianceGenome:MGI:2444783
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EFG2; MST027; RRF2mt; EF-G2mt; 6530419G12Rik; A930009M04Rik
Summary
Predicted to enable GTPase activity. Predicted to be involved in mitochondrial translation and ribosome disassembly. Located in mitochondrion. Is expressed in brain; dorsal root ganglion; liver lobe; spinal cord; and thymus primordium. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 39. Orthologous to human GFM2 (GTP dependent ribosome recycling factor mitochondrial 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 8.7), kidney adult (RPKM 6.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gfm2 in Genome Data Viewer
Location:
13 D1; 13 50.66 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (97274445..97317710)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (97137933..97181202)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 169, member A Neighboring gene proteolipid protein 2, retrotransposed Neighboring gene STARR-positive B cell enhancer ABC_E3094 Neighboring gene NSA2 ribosome biogenesis homolog Neighboring gene hexosaminidase B Neighboring gene STARR-seq mESC enhancer starr_35367 Neighboring gene STARR-seq mESC enhancer starr_35370 Neighboring gene ectodermal-neural cortex 1 Neighboring gene STARR-seq mESC enhancer starr_35377 Neighboring gene predicted gene, 33390

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gut colonization by Bacteroides requires translation by an EF-G paralog lacking GTPase activity. Han W, et al. EMBO J, 2023 Jan 16. PMID 36472247, Free PMC Article
  2. Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue. Chavez JD, et al. Cell Syst, 2018 Jan 24. PMID 29199018, Free PMC Article
  3. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Schweppe DK, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28130547, Free PMC Article
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gut colonization by Bacteroides requires translation by an EF-G paralog lacking GTPase activity.
    Title: Gut colonization by Bacteroides requires translation by an EF-G paralog lacking GTPase activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ribosome disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosome disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
ribosome-releasing factor 2, mitochondrial
NP_001139515.1
NP_001258392.1
NP_001258393.1
NP_001258394.1
NP_796240.3
XP_006517752.1
XP_006517753.1
XP_006517754.1
XP_030103160.1
XP_030103161.1
XP_030103162.1
XP_030103163.1
XP_036013965.1
XP_036013966.1
XP_036013967.1
XP_036013968.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146043.2 → NP_001139515.1  ribosome-releasing factor 2, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001139515.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a different terminal exon for its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154620, AI666524, AK044371, AK161797
    Consensus CDS
    CCDS49338.1
    UniProtKB/TrEMBL
    E9Q7N5, Q3TSU6
    Related
    ENSMUSP00000125088.2, ENSMUST00000161825.8
    Conserved Domains (1) summary
    PRK13351
    Location:64 → 732
    PRK13351; elongation factor G-like protein

  2. NM_001271463.1 → NP_001258392.1  ribosome-releasing factor 2, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_001258392.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC154620, AK035819, AK044371
    Consensus CDS
    CCDS26708.2
    UniProtKB/Swiss-Prot
    B2RR55, Q8BXS5, Q8R2Q4
    UniProtKB/TrEMBL
    Q3TSU6
    Conserved Domains (1) summary
    PRK12739
    Location:66 → 774
    PRK12739; elongation factor G; Reviewed

  3. NM_001271464.1 → NP_001258393.1  ribosome-releasing factor 2, mitochondrial isoform 3

    See identical proteins and their annotated locations for NP_001258393.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and lacks an in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC154620, AK044371
    Consensus CDS
    CCDS70490.1
    UniProtKB/TrEMBL
    Q3TSU6
    Related
    ENSMUSP00000048373.7, ENSMUST00000042084.13
    Conserved Domains (1) summary
    PRK12739
    Location:66 → 747
    PRK12739; elongation factor G; Reviewed

  4. NM_001271465.1 → NP_001258394.1  ribosome-releasing factor 2, mitochondrial isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC154620, AK035819, AK044371
    Consensus CDS
    CCDS70491.1
    UniProtKB/TrEMBL
    Q3TSU6
    Related
    ENSMUSP00000022170.8, ENSMUST00000022170.8
    Conserved Domains (1) summary
    PRK13351
    Location:62 → 757
    PRK13351; elongation factor G-like protein

  5. NM_177266.5 → NP_796240.3  ribosome-releasing factor 2, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_796240.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC154620, AK035819, AK044371
    Consensus CDS
    CCDS26708.2
    UniProtKB/Swiss-Prot
    B2RR55, Q8BXS5, Q8R2Q4
    UniProtKB/TrEMBL
    Q3TSU6
    Related
    ENSMUSP00000125656.2, ENSMUST00000161639.8
    Conserved Domains (1) summary
    PRK12739
    Location:66 → 774
    PRK12739; elongation factor G; Reviewed

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    97274445..97317710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517690.5 → XP_006517753.1  ribosome-releasing factor 2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006517753.1

    UniProtKB/Swiss-Prot
    B2RR55, Q8BXS5, Q8R2Q4
    UniProtKB/TrEMBL
    Q3TSU6
    Conserved Domains (1) summary
    PRK12739
    Location:66 → 774
    PRK12739; elongation factor G; Reviewed

  2. XM_036158074.1 → XP_036013967.1  ribosome-releasing factor 2, mitochondrial isoform X2

    UniProtKB/TrEMBL
    Q3TSU6
    Conserved Domains (1) summary
    PRK12739
    Location:66 → 747
    PRK12739; elongation factor G; Reviewed

  3. XM_006517691.5 → XP_006517754.1  ribosome-releasing factor 2, mitochondrial isoform X3

    See identical proteins and their annotated locations for XP_006517754.1

    UniProtKB/TrEMBL
    E9Q7N5, Q3TSU6
    Conserved Domains (1) summary
    PRK13351
    Location:64 → 732
    PRK13351; elongation factor G-like protein

  4. XM_036158073.1 → XP_036013966.1  ribosome-releasing factor 2, mitochondrial isoform X2

    UniProtKB/TrEMBL
    Q3TSU6
    Conserved Domains (1) summary
    PRK12739
    Location:66 → 747
    PRK12739; elongation factor G; Reviewed

  5. XM_030247303.2 → XP_030103163.1  ribosome-releasing factor 2, mitochondrial isoform X4

    Conserved Domains (1) summary
    PRK12740
    Location:1 → 573
    PRK12740; elongation factor G-like protein EF-G2

  6. XM_030247300.2 → XP_030103160.1  ribosome-releasing factor 2, mitochondrial isoform X4

    Conserved Domains (1) summary
    PRK12740
    Location:1 → 573
    PRK12740; elongation factor G-like protein EF-G2

  7. XM_036158075.1 → XP_036013968.1  ribosome-releasing factor 2, mitochondrial isoform X5

    Conserved Domains (1) summary
    PRK12740
    Location:1 → 546
    PRK12740; elongation factor G-like protein EF-G2

  8. XM_030247302.2 → XP_030103162.1  ribosome-releasing factor 2, mitochondrial isoform X4

    Conserved Domains (1) summary
    PRK12740
    Location:1 → 573
    PRK12740; elongation factor G-like protein EF-G2

  9. XM_006517689.5 → XP_006517752.1  ribosome-releasing factor 2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006517752.1

    UniProtKB/Swiss-Prot
    B2RR55, Q8BXS5, Q8R2Q4
    UniProtKB/TrEMBL
    Q3TSU6
    Conserved Domains (1) summary
    PRK12739
    Location:66 → 774
    PRK12739; elongation factor G; Reviewed

  10. XM_030247301.2 → XP_030103161.1  ribosome-releasing factor 2, mitochondrial isoform X4

    Conserved Domains (1) summary
    PRK12740
    Location:1 → 573
    PRK12740; elongation factor G-like protein EF-G2

  11. XM_036158072.1 → XP_036013965.1  ribosome-releasing factor 2, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    B2RR55, Q8BXS5, Q8R2Q4
    UniProtKB/TrEMBL
    Q3TSU6
    Conserved Domains (1) summary
    PRK12739
    Location:66 → 774
    PRK12739; elongation factor G; Reviewed

RNA

  1. XR_004938030.1 RNA Sequence

  2. XR_004938031.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2Q4.2 GenPept UniProtKB/Swiss-Prot:Q8R2Q4

Gene LinkOut

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