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Ankrd16 ankyrin repeat domain 16 [ Mus musculus (house mouse) ]

Gene ID: 320816, updated on 28-Oct-2024

Summary

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Official Symbol
Ankrd16provided by MGI
Official Full Name
ankyrin repeat domain 16provided by MGI
Primary source
MGI:MGI:2444796
See related
Ensembl:ENSMUSG00000047909 AllianceGenome:MGI:2444796
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810455F06Rik; D430029B21Rik
Summary
Involved in tRNA modification. Located in cytoplasm and nucleus. Orthologous to human ANKRD16 (ankyrin repeat domain 16). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 16.4), CNS E14 (RPKM 15.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ankrd16 in Genome Data Viewer
Location:
2 A1; 2 9.05 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (11781902..11795138)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (11777753..11790327)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene interleukin 15 receptor, alpha chain Neighboring gene predicted gene, 46731 Neighboring gene F-box DNA helicase 1 Neighboring gene STARR-positive B cell enhancer ABC_E804 Neighboring gene STARR-seq mESC enhancer starr_03678 Neighboring gene STARR-seq mESC enhancer starr_03679 Neighboring gene predicted gene, 34768 Neighboring gene ankyrin repeat domain-containing protein 20A12 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase. Vo MN, et al. Nature, 2018 May. PMID 29769718, Free PMC Article
  2. Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs. Wang Q, et al. BMC Genomics, 2011 Apr 21. PMID 21510876, Free PMC Article
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA modification IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363082.1 → NP_001350011.1  ankyrin repeat domain-containing protein 16 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL845548
    Conserved Domains (3) summary
    sd00045
    Location:59 → 91
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:1 → 46
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:30 → 125
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_177268.4 → NP_796242.2  ankyrin repeat domain-containing protein 16 isoform 1

    See identical proteins and their annotated locations for NP_796242.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL845548
    Consensus CDS
    CCDS50502.1
    UniProtKB/Swiss-Prot
    A2AS55, Q8BH84
    Related
    ENSMUSP00000052056.6, ENSMUST00000056108.12
    Conserved Domains (3) summary
    cd00204
    Location:37 → 157
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:41 → 134
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:37 → 68
    ANK; ANK repeat [structural motif]

RNA

  1. NR_156440.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL845548

  2. NR_156441.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL845548

  3. NR_156442.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL845548

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    11781902..11795138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238978.3 → XP_011237280.1  ankyrin repeat domain-containing protein 16 isoform X1

    Conserved Domains (3) summary
    COG0666
    Location:33 → 158
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:37 → 68
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:175 → 304
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_036162312.1 → XP_036018205.1  ankyrin repeat domain-containing protein 16 isoform X2

    UniProtKB/TrEMBL
    Q3USW0
    Conserved Domains (2) summary
    COG0666
    Location:33 → 158
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:37 → 68
    ANK; ANK repeat [structural motif]

  3. XM_030251769.2 → XP_030107629.1  ankyrin repeat domain-containing protein 16 isoform X4

    Conserved Domains (3) summary
    sd00045
    Location:59 → 91
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:1 → 46
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:30 → 125
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_036162313.1 → XP_036018206.1  ankyrin repeat domain-containing protein 16 isoform X3

    Conserved Domains (3) summary
    sd00045
    Location:69 → 101
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:9 → 56
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:40 → 135
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_036162314.1 → XP_036018207.1  ankyrin repeat domain-containing protein 16 isoform X4

    Conserved Domains (3) summary
    sd00045
    Location:59 → 91
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:1 → 46
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:30 → 125
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. XR_004940636.1 RNA Sequence

  2. XR_004940638.1 RNA Sequence

  3. XR_004940632.1 RNA Sequence

  4. XR_004940629.1 RNA Sequence

  5. XR_004940631.1 RNA Sequence

  6. XR_004940639.1 RNA Sequence

  7. XR_004940637.1 RNA Sequence

  8. XR_004940630.1 RNA Sequence

  9. XR_004940640.1 RNA Sequence

  10. XR_004940645.1 RNA Sequence

  11. XR_004940644.1 RNA Sequence

  12. XR_004940643.1 RNA Sequence

  13. XR_004940633.1 RNA Sequence

  14. XR_004940641.1 RNA Sequence

  15. XR_003953500.2 RNA Sequence

  16. XR_004940635.1 RNA Sequence

  17. XR_373941.3 RNA Sequence

  18. XR_004940634.1 RNA Sequence

  19. XR_004940642.1 RNA Sequence

  20. XR_003953498.2 RNA Sequence

  21. XR_004940627.1 RNA Sequence

  22. XR_004940628.1 RNA Sequence

  23. XR_003953497.2 RNA Sequence

  24. XR_373938.2 RNA Sequence

  25. XR_373937.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AS55.1 GenPept UniProtKB/Swiss-Prot:A2AS55

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