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Cracd capping protein inhibiting regulator of actin [ Mus musculus (house mouse) ]

Gene ID: 320827, updated on 2-Nov-2024

Summary

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Official Symbol
Cracdprovided by MGI
Official Full Name
capping protein inhibiting regulator of actinprovided by MGI
Primary source
MGI:MGI:2444817
See related
Ensembl:ENSMUSG00000036377 AllianceGenome:MGI:2444817
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crad; Gm10430; mKIAA1211; 2810489J07Rik; 4930529A19Rik; 4931405B09Rik; C530008M17Rik
Summary
Involved in maintenance of gastrointestinal epithelium. Predicted to be located in cytosol. Is expressed in several structures, including gut; heart and pericardium; nervous system; skin; and testis. Orthologous to human CRACD (capping protein inhibiting regulator of actin dynamics). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 47.4), CNS E18 (RPKM 17.4) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Cracd in Genome Data Viewer
Location:
5 C3.3; 5 41.34 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (76803225..77021393)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (76657629..76873554)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1053 Neighboring gene exocyst complex component 1 Neighboring gene centrosomal protein 135 Neighboring gene predicted gene, 57768 Neighboring gene ribosomal protein L23a pseudogene Neighboring gene predicted gene, 34369 Neighboring gene STARR-seq mESC enhancer starr_13449 Neighboring gene STARR-seq mESC enhancer starr_13451 Neighboring gene predicted gene, 52818 Neighboring gene STARR-seq mESC enhancer starr_13452 Neighboring gene aminoadipate-semialdehyde dehydrogenase Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CRACD loss induces neuroendocrine cell plasticity of lung adenocarcinoma. Kim B, et al. Cell Rep, 2024 Jun 25. PMID 38796854, Free PMC Article
  2. Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis. Snider PL, et al. J Cardiovasc Dev Dis, 2019 Jun 22. PMID 31234534, Free PMC Article
  3. Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin. Jung YS, et al. Nat Cell Biol, 2018 Nov. PMID 30361697, Free PMC Article
  4. Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry. Del Mar Masdeu M, et al. Oncotarget, 2017 Nov 24. PMID 29254152, Free PMC Article
  5. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRACD loss induces neuroendocrine cell plasticity of lung adenocarcinoma.
    Title: CRACD loss induces neuroendocrine cell plasticity of lung adenocarcinoma.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • KIAA1211

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in epithelial structure maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of gastrointestinal epithelium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maintenance of gastrointestinal epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of barbed-end actin filament capping ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of barbed-end actin filament capping ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
capping protein-inhibiting regulator of actin dynamics
Names
cancer-related regulator of actin dynamics
capping protein inhibiting regulator of actin dynamics

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163793.2 → NP_001157265.1  capping protein-inhibiting regulator of actin dynamics isoform 2

    See identical proteins and their annotated locations for NP_001157265.1

    Status: VALIDATED

    Source sequence(s)
    AC166328
    Consensus CDS
    CCDS51526.1
    UniProtKB/TrEMBL
    A0A5F8MPP1
    Related
    ENSMUSP00000113796.3, ENSMUST00000120639.9
    Conserved Domains (3) summary
    PTZ00449
    Location:956 → 1267
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03307
    Location:694 → 1106
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15262
    Location:45 → 172
    DUF4592; Domain of unknown function (DUF4592)

  2. NM_001408677.1 → NP_001395606.1  capping protein-inhibiting regulator of actin dynamics isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124978, AC127332, AC166328

  3. NM_001408678.1 → NP_001395607.1  capping protein-inhibiting regulator of actin dynamics isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC124978, AC127332, AC166328

  4. NM_001408679.1 → NP_001395608.1  capping protein-inhibiting regulator of actin dynamics isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC124978, AC166328
    UniProtKB/TrEMBL
    D3YTS2

  5. NM_001408680.1 → NP_001395609.1  capping protein-inhibiting regulator of actin dynamics isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC166328
    UniProtKB/TrEMBL
    D3YTS2
    Related
    ENSMUSP00000113485.2, ENSMUST00000120818.8

  6. NM_177272.3 → NP_796246.2  capping protein-inhibiting regulator of actin dynamics isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124978, AC127332, AC166328
    UniProtKB/Swiss-Prot
    E9Q3Y7, E9Q5L4, E9QLP4, Q5PR69, Q80TH6, Q8C7K8, Q8C7R0, Q8C9F2, Q8CDM6
    Related
    ENSMUSP00000113947.2, ENSMUST00000121160.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    76803225..77021393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320926.3 → XP_017176415.1  capping protein-inhibiting regulator of actin dynamics isoform X6

    UniProtKB/TrEMBL
    A0A5F8MPP1
    Conserved Domains (3) summary
    PTZ00449
    Location:956 → 1270
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03307
    Location:694 → 1106
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15262
    Location:45 → 172
    DUF4592; Domain of unknown function (DUF4592)

  2. XM_006535007.4 → XP_006535070.1  capping protein-inhibiting regulator of actin dynamics isoform X6

    UniProtKB/TrEMBL
    A0A5F8MPP1
    Conserved Domains (3) summary
    PTZ00449
    Location:956 → 1270
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03307
    Location:694 → 1106
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15262
    Location:45 → 172
    DUF4592; Domain of unknown function (DUF4592)

  3. XM_006535004.4 → XP_006535067.1  capping protein-inhibiting regulator of actin dynamics isoform X5

    See identical proteins and their annotated locations for XP_006535067.1

    UniProtKB/Swiss-Prot
    E9Q3Y7, E9Q5L4, E9QLP4, Q5PR69, Q80TH6, Q8C7K8, Q8C7R0, Q8C9F2, Q8CDM6
    UniProtKB/TrEMBL
    A0A5F8MPP1
    Conserved Domains (3) summary
    PTZ00449
    Location:956 → 1270
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03307
    Location:694 → 1106
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15262
    Location:45 → 172
    DUF4592; Domain of unknown function (DUF4592)

  4. XM_006535011.4 → XP_006535074.1  capping protein-inhibiting regulator of actin dynamics isoform X7

    See identical proteins and their annotated locations for XP_006535074.1

    UniProtKB/TrEMBL
    A0A5F8MPP1
    Conserved Domains (3) summary
    PTZ00449
    Location:898 → 1212
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03307
    Location:636 → 1048
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15262
    Location:1 → 114
    DUF4592; Domain of unknown function (DUF4592)

  5. XM_030254581.2 → XP_030110441.1  capping protein-inhibiting regulator of actin dynamics isoform X5

    UniProtKB/Swiss-Prot
    E9Q3Y7, E9Q5L4, E9QLP4, Q5PR69, Q80TH6, Q8C7K8, Q8C7R0, Q8C9F2, Q8CDM6
    UniProtKB/TrEMBL
    A0A5F8MPP1
    Conserved Domains (3) summary
    PTZ00449
    Location:956 → 1270
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03307
    Location:694 → 1106
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15262
    Location:45 → 172
    DUF4592; Domain of unknown function (DUF4592)

  6. XM_030254580.1 → XP_030110440.1  capping protein-inhibiting regulator of actin dynamics isoform X5

    UniProtKB/Swiss-Prot
    E9Q3Y7, E9Q5L4, E9QLP4, Q5PR69, Q80TH6, Q8C7K8, Q8C7R0, Q8C9F2, Q8CDM6
    UniProtKB/TrEMBL
    A0A5F8MPP1
    Conserved Domains (3) summary
    PTZ00449
    Location:956 → 1270
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03307
    Location:694 → 1106
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15262
    Location:45 → 172
    DUF4592; Domain of unknown function (DUF4592)

  7. XM_011249480.1 → XP_011247782.1  capping protein-inhibiting regulator of actin dynamics isoform X1

    See identical proteins and their annotated locations for XP_011247782.1

    UniProtKB/TrEMBL
    A0A5F8MPP1
    Conserved Domains (3) summary
    PTZ00449
    Location:956 → 1267
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03307
    Location:694 → 1106
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15262
    Location:45 → 172
    DUF4592; Domain of unknown function (DUF4592)

  8. XM_011249481.1 → XP_011247783.1  capping protein-inhibiting regulator of actin dynamics isoform X2

    UniProtKB/TrEMBL
    A0A5F8MPP1
    Conserved Domains (2) summary
    PHA03307
    Location:694 → 1106
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15262
    Location:45 → 172
    DUF4592; Domain of unknown function (DUF4592)

  9. XM_030254579.1 → XP_030110439.1  capping protein-inhibiting regulator of actin dynamics isoform X3

    UniProtKB/TrEMBL
    A0A5F8MPP1
    Conserved Domains (3) summary
    PTZ00449
    Location:956 → 1120
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03307
    Location:694 → 1106
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15262
    Location:45 → 172
    DUF4592; Domain of unknown function (DUF4592)

  10. XM_011249482.4 → XP_011247784.1  capping protein-inhibiting regulator of actin dynamics isoform X5

    See identical proteins and their annotated locations for XP_011247784.1

    UniProtKB/Swiss-Prot
    E9Q3Y7, E9Q5L4, E9QLP4, Q5PR69, Q80TH6, Q8C7K8, Q8C7R0, Q8C9F2, Q8CDM6
    UniProtKB/TrEMBL
    A0A5F8MPP1
    Conserved Domains (3) summary
    PTZ00449
    Location:956 → 1270
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03307
    Location:694 → 1106
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15262
    Location:45 → 172
    DUF4592; Domain of unknown function (DUF4592)

  11. XM_006535008.2 → XP_006535071.1  capping protein-inhibiting regulator of actin dynamics isoform X5

    See identical proteins and their annotated locations for XP_006535071.1

    UniProtKB/Swiss-Prot
    E9Q3Y7, E9Q5L4, E9QLP4, Q5PR69, Q80TH6, Q8C7K8, Q8C7R0, Q8C9F2, Q8CDM6
    UniProtKB/TrEMBL
    A0A5F8MPP1
    Conserved Domains (3) summary
    PTZ00449
    Location:956 → 1270
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03307
    Location:694 → 1106
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15262
    Location:45 → 172
    DUF4592; Domain of unknown function (DUF4592)

  12. XM_006535002.5 → XP_006535065.1  capping protein-inhibiting regulator of actin dynamics isoform X4

    UniProtKB/TrEMBL
    A0A5F8MPP1
    Conserved Domains (3) summary
    PTZ00449
    Location:962 → 1276
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03307
    Location:700 → 1112
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15262
    Location:51 → 178
    DUF4592; Domain of unknown function (DUF4592)

RNA

  1. XR_004942527.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027611.2: Suppressed sequence

    Description
    NM_027611.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PR69.4 GenPept UniProtKB/Swiss-Prot:Q5PR69

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