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Serpina4-ps1 serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1 [ Mus musculus (house mouse) ]

Gene ID: 321018, updated on 2-Nov-2024

Summary

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Official Symbol
Serpina4-ps1provided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1provided by MGI
Primary source
MGI:MGI:2448363
See related
Ensembl:ENSMUSG00000120841 AllianceGenome:MGI:2448363
Gene type
pseudo
RefSeq status
INFERRED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Klst; KALps
Summary
Is expressed in liver; spleen; and thymus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward liver E18 (RPKM 43.9) See more
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Genomic context

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See Serpina4-ps1 in Genome Data Viewer
Location:
12 E; 12 53.23 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (104044218..104053179)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (104077959..104086920)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 Neighboring gene predicted gene, 31271 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 5 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Kallistatin exerts anti-lymphangiogenic effects by inhibiting lymphatic endothelial cell proliferation, migration and tube formation. Ma C, et al. Int J Oncol, 2017 Jun. PMID 28440474, Free PMC Article
  2. Antiangiogenic and antineuroinflammatory effects of kallistatin through interactions with the canonical Wnt pathway. Liu X, et al. Diabetes, 2013 Dec. PMID 23884893, Free PMC Article
  3. Kallistatin attenuates endothelial senescence by modulating Let-7g-mediated miR-34a-SIRT1-eNOS pathway. Guo Y, et al. J Cell Mol Med, 2018 Sep. PMID 29992759, Free PMC Article
  4. Kallikrein-binding protein suppresses growth of hepatocellular carcinoma by anti-angiogenic activity. Lu L, et al. Cancer Lett, 2007 Nov 8. PMID 17714861
  5. A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins. Forsyth S, et al. Genomics, 2003 Mar. PMID 12659817

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endogenous kallistatin through novel mechanisms protects against endothelial senescence by modulating Let-7g-mediated miR-34a-SIRT1-eNOS pathway.
    Title: Kallistatin attenuates endothelial senescence by modulating Let-7g-mediated miR-34a-SIRT1-eNOS pathway.
  2. our results showed that the lymphatic vessel density (LVD) was reduced in lung and stomach sections from kallistatin-overexpressing transgenic mice
    Title: Kallistatin exerts anti-lymphangiogenic effects by inhibiting lymphatic endothelial cell proliferation, migration and tube formation.
  3. KBP reduces expression of VEGF and HIF-1alpha nuclear translocation
    Title: Kallikrein-binding protein suppresses growth of hepatocellular carcinoma by anti-angiogenic activity.
Submit: New GeneRIF Correction

General gene information

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Markers

Other Names

  • kallistatin related protein
  • serine (or cysteine) proteinase inhibitor, clade A, member 4, pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_002861.2 RNA Sequence

    Status: INFERRED

    Source sequence(s)
    AC114552, AC142112
    Related
    ENSMUST00000311839.1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    104044218..104053179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177315.1: Suppressed sequence

    Description
    NM_177315.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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