Gpr183 G protein-coupled receptor 183 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr183provided by MGI
Official Full Name: G protein-coupled receptor 183provided by MGI
Primary source: MGI:MGI:2442034
See related: Ensembl:ENSMUSG00000051212 AllianceGenome:MGI:2442034
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ebi2
Summary: Enables oxysterol binding activity. Involved in several processes, including dendritic cell homeostasis; leukocyte chemotaxis; and leukocyte differentiation. Acts upstream of or within leukocyte chemotaxis. Predicted to be located in plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; intestine; and retina. Orthologous to human GPR183 (G protein-coupled receptor 183). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 9.1), mammary gland adult (RPKM 4.9) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 E5; 14 65.86 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (122189743..122202605, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (121952331..121965193, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of G-protein-coupled receptor 183 initiates inflammatory pain via macrophage CCL22 secretion.
Title: Activation of G-protein-coupled receptor 183 initiates inflammatory pain via macrophage CCL22 secretion.
The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus.
Title: The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus.
GPR183 Regulates 7alpha,25-Dihydroxycholesterol-Induced Oxiapoptophagy in L929 Mouse Fibroblast Cell.
Title: GPR183 Regulates 7α,25-Dihydroxycholesterol-Induced Oxiapoptophagy in L929 Mouse Fibroblast Cell.
Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection.
Title: Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection.
A Blunted GPR183/Oxysterol Axis During Dysglycemia Results in Delayed Recruitment of Macrophages to the Lung During Mycobacterium tuberculosis Infection.
Title: A Blunted GPR183/Oxysterol Axis During Dysglycemia Results in Delayed Recruitment of Macrophages to the Lung During Mycobacterium tuberculosis Infection.
EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes.
Title: EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes.
GPR183 Is Dispensable for B1 Cell Accumulation and Function, but Affects B2 Cell Abundance, in the Omentum and Peritoneal Cavity.
Title: GPR183 Is Dispensable for B1 Cell Accumulation and Function, but Affects B2 Cell Abundance, in the Omentum and Peritoneal Cavity.
GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity.
Title: GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity.
these data implicate the EBI2-oxysterol axis in inflammatory bowel disease pathogenesis
Title: The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis.
This study support the hypothesis that EBI2/oxysterol signalling not only controls immune cell function, but may also adjust how astrocytes sense and respond to inflammatory stimuli
Title: EBI2 regulates pro-inflammatory signalling and cytokine release in astrocytes.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxysterol binding	IDA Inferred from Direct Assay more info	PubMed
enables oxysterol binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T follicular helper cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adaptive immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in humoral immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leukocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in leukocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in mature B cell differentiation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of B cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of astrocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in regulation of astrocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: G-protein coupled receptor 183

Names: EBV-induced G-protein coupled receptor 2 homolog; Epstein-Barr virus induced gene 2; epstein-Barr virus-induced G-protein coupled receptor 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183031.2 → NP_898852.2 G-protein coupled receptor 183

See identical proteins and their annotated locations for NP_898852.2

Status: VALIDATED

Source sequence(s)

AK138693, AK141593, BB525541

Consensus CDS

CCDS27343.1

UniProtKB/Swiss-Prot

Q3U1F6, Q3U6B2, Q7TMV7, Q80T40

Related

ENSMUSP00000052404.8, ENSMUST00000049872.9

Conserved Domains (1) summary

cd15159
Location:28 → 315

7tmA_EBI2; Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

122189743..122202605 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158676.1 → XP_036014569.1 G-protein coupled receptor 183 isoform X1

UniProtKB/Swiss-Prot

Q3U1F6, Q3U6B2, Q7TMV7, Q80T40

Conserved Domains (1) summary

cd15159
Location:28 → 315

7tmA_EBI2; Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors