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kat7b K(lysine) acetyltransferase 7b [ Danio rerio (zebrafish) ]

Gene ID: 323181, updated on 18-Sep-2024

Summary

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Official Symbol
kat7bprovided by ZNC
Official Full Name
K(lysine) acetyltransferase 7bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1901
See related
Ensembl:ENSDARG00000031770 AllianceGenome:ZFIN:ZDB-GENE-030131-1901
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
kat7; myst2; fi16d05; wu:fb92a01; wu:fi16d05
Summary
Predicted to enable histone acetyltransferase activity; histone binding activity; and transcription coregulator activity. Acts upstream of or within blood vessel development. Predicted to be located in nucleus. Orthologous to human KAT7 (lysine acetyltransferase 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See kat7b in Genome Data Viewer
Location:
chromosome: 12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (5981333..5998900, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (5947749..5965280, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene distal-less homeobox 3b Neighboring gene distal-less homeobox 4b Neighboring gene si:ch211-131k2.2 Neighboring gene prostaglandin E synthase 3 like Neighboring gene glucose-6-phosphatase catalytic subunit 1a, tandem duplicate 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Histone acetyltransferase 7 (KAT7)-dependent intragenic histone acetylation regulates endothelial cell gene regulation. Yan MS, et al. J Biol Chem, 2018 Mar 23. PMID 29414790, Free PMC Article
  2. Cytoplasmic polyadenylation-mediated translational control of maternal mRNAs directs maternal-to-zygotic transition. Winata CL, et al. Development, 2018 Jan 8. PMID 29229769
  3. Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos. Wu Y, et al. Sci Rep, 2017 Jun 22. PMID 28642470, Free PMC Article
  4. Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition. Aanes H, et al. Genome Res, 2011 Aug. PMID 21555364, Free PMC Article
  5. Identification and expression of mangrove rivulus (Kryptolebias marmoratus) histone deacetylase (HDAC) and lysine acetyltransferase (KAT) genes. Fellous A, et al. Gene, 2019 Apr 5. PMID 30615915

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H4 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of histone H3-K14 acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histone acetyltransferase KAT7
Names
K(lysine) acetyltransferase 7
MYST histone acetyltransferase 2
MYST-HAT2
NP_997800.1
XP_021335701.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212635.1 → NP_997800.1  histone acetyltransferase KAT7

    See identical proteins and their annotated locations for NP_997800.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045314
    UniProtKB/TrEMBL
    Q6DI19, Q7ZW29
    Related
    ENSDARP00000021648.8, ENSDART00000004896.10
    Conserved Domains (3) summary
    pfam01530
    Location:144 → 170
    zf-C2HC; Zinc finger, C2HC type
    pfam01853
    Location:351 → 529
    MOZ_SAS; MOZ/SAS family
    cl17182
    Location:287 → 545
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    5981333..5998900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480026.2 → XP_021335701.1  histone acetyltransferase KAT7 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QIK1
    Conserved Domains (2) summary
    pfam01530
    Location:127 → 155
    zf-C2HC; Zinc finger, C2HC type
    cl27485
    Location:190 → 549
    MOZ_SAS; MOZ/SAS family
Nucleotide Protein Strain
Heading Accession and Version

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