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HUWE1 - HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1

Predicted to enable ubiquitin protein ligase activity. Involved in several processes, including dsRNA transport; negative regulation of signal transduction; and regulation of axonogenesis. Located in nucleus. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Orthologous to human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Oct 2024]

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Species Gene Architecture aa