HPX hemopexin [Homo sapiens (human)] - Gene

Summary

Official Symbol: HPXprovided by HGNC
Official Full Name: hemopexinprovided by HGNC
Primary source: HGNC:HGNC:5171
See related: Ensembl:ENSG00000110169 MIM:142290; AllianceGenome:HGNC:5171
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HX
Summary: This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]
Expression: Restricted expression toward liver (RPKM 1209.1) See more
Orthologs: mouse all
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Genomic context

Location:: 11p15.4

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (6431049..6440987, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (6489509..6499449, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (6452279..6462217, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Free heme and hemopexin in acute kidney injury after cardiopulmonary bypass and transient renal ischemia.
Title: Free heme and hemopexin in acute kidney injury after cardiopulmonary bypass and transient renal ischemia.
Heme oxygenase-1 and hemopexin gene polymorphisms and the risk of anti-tuberculosis drug-induced hepatotoxicity in China.
Title: Heme oxygenase-1 and hemopexin gene polymorphisms and the risk of anti-tuberculosis drug-induced hepatotoxicity in China.
Evaluation of the relationship between intravascular hemolysis and clinical manifestations in sickle cell disease: decreased hemopexin during vaso-occlusive crises and increased inflammation in acute chest syndrome.
Title: Evaluation of the relationship between intravascular hemolysis and clinical manifestations in sickle cell disease: decreased hemopexin during vaso-occlusive crises and increased inflammation in acute chest syndrome.
Widespread severe cerebral elevations of haptoglobin and haemopexin in sporadic Alzheimer's disease: Evidence for a pervasive microvasculopathy.
Title: Widespread severe cerebral elevations of haptoglobin and haemopexin in sporadic Alzheimer's disease: Evidence for a pervasive microvasculopathy.
Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases.
Title: Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases.
Hemopexin and alpha1-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction.
Title: Hemopexin and α1-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction.
Study found that hemopexin was significantly higher in acute T cell-mediated rejection (TCMR) patients and could be detected in urine of kidney transplant recipients which makes it s potential diagnostic protein for TCMR.
Title: Novel urinary exosomal biomarkers of acute T cell-mediated rejection in kidney transplant recipients: A cross-sectional study.
Data suggest that apo-hemopexin isolated from plasma exchibits low endogenous levels of tyrosine nitration in the peptide YYCFQGNQFLR in the heme-binding site of human hemopexin, which was similarly nitrated in rabbit and rat hemopexins; heme binding by hemopexin declined as tyrosine nitration proceeded in vitro.
Title: Identification of oxidative modifications of hemopexin and their predicted physiological relevance.
There were significantly higher serum concentrations of fetal hemoglobin and alpha1-microglobulin and significantly lower first trimester serum concentrations of hemopexin in patients who later developed preeclampsia.
Title: Fetal hemoglobin, α1-microglobulin and hemopexin are potential predictive first trimester biomarkers for preeclampsia.
HPX is upregulated in non-small cell lung cancer patients compared to those with benign lung disease or no lung disease.
Title: Identification of GlcNAcylated alpha-1-antichymotrypsin as an early biomarker in human non-small-cell lung cancer by quantitative proteomic analysis with two lectins.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

HPX (e-PCR)
- UniSTS:43318

GDB:197845 (e-PCR)
- UniSTS:155963

D11S4353 (e-PCR)
- UniSTS:30347

RH11711 (e-PCR)
- UniSTS:30348

D11S4588 (e-PCR)
- UniSTS:68264

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables heme transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in heme metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme transport	IEA Inferred from Electronic Annotation more info
involved_in hemoglobin metabolic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular iron ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of humoral immune response mediated by circulating immunoglobulin	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of immunoglobulin production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type II interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IEA Inferred from Electronic Annotation more info
involved_in type II interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in blood microparticle	HDA more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in endocytic vesicle lumen	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hemopexin

Names: beta-1B-glycoprotein; epididymis secretory sperm binding protein

NP_000604.1

EC 3.2.1.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000613.3 → NP_000604.1 hemopexin precursor

See identical proteins and their annotated locations for NP_000604.1

Status: REVIEWED

Source sequence(s)

AK313648, AV655383, BC005395

Consensus CDS

CCDS7763.1

UniProtKB/Swiss-Prot

B2R957, P02790

Related

ENSP00000265983.3, ENST00000265983.8

Conserved Domains (1) summary

cd00094
Location:47 → 231

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...