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HRH1 histamine receptor H1 [ Homo sapiens (human) ]

Gene ID: 3269, updated on 11-Apr-2024

Summary

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Official Symbol
HRH1provided by HGNC
Official Full Name
histamine receptor H1provided by HGNC
Primary source
HGNC:HGNC:5182
See related
Ensembl:ENSG00000196639 MIM:600167; AllianceGenome:HGNC:5182
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H1R; H1-R; HH1R; hisH1
Summary
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]
Expression
Ubiquitous expression in brain (RPKM 4.0), urinary bladder (RPKM 3.8) and 21 other tissues See more
Orthologs
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Genomic context

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See HRH1 in Genome Data Viewer
Location:
3p25.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (11137238..11263557)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (11131678..11258484)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (11178924..11305243)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SLC6A1 antisense RNA 1 Neighboring gene solute carrier family 6 member 1 Neighboring gene Sharpr-MPRA regulatory region 1670 Neighboring gene uncharacterized LOC101927467 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:11178289-11179488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19425 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19426 Neighboring gene uncharacterized LOC105376951 Neighboring gene uncharacterized LOC124909345 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:11208446-11208946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:11208947-11209447 Neighboring gene uncharacterized LOC102723663 Neighboring gene Sharpr-MPRA regulatory region 13806 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:11299925-11300126 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4 pseudogene 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:11313687-11314278 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:11314279-11314868 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:11328313-11328445 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:11330264-11331463 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19429 Neighboring gene ribosomal protein L13a pseudogene 27 Neighboring gene autophagy related 7 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:11405755-11406954 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:11521898-11522503 Neighboring gene CSTB pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Differential regulation of histamine H(1) receptor-mediated ERK phosphorylation by G(q) proteins and arrestins. Michinaga S, et al. Biochem Pharmacol, 2023 Jul. PMID 37201878
  2. Epigallocatechin gallate stimulated histamine production and downregulated histamine H1 receptor in oral cancer cell lines expressing histidine decarboxylase. Kon M, et al. J Oral Biosci, 2022 Mar. PMID 35031480
  3. Molecular Signaling and Transcriptional Regulation of Histamine H(1) Receptor Gene. Mizuguchi H, et al. Curr Top Behav Neurosci, 2022. PMID 34595742
  4. Analysis of Missense Variants in the Human Histamine Receptor Family Reveals Increased Constitutive Activity of E410(6.30×30)K Variant in the Histamine H(1) Receptor. Ma X, et al. Int J Mol Sci, 2021 Apr 2. PMID 33918180, Free PMC Article
  5. Histamine receptor 1 is expressed in leukaemic cells and affects differentiation sensitivity. Cornet-Masana JM, et al. J Cell Mol Med, 2020 Nov. PMID 33080103, Free PMC Article

See all (115) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Histamine H1 Receptor-Mediated JNK Phosphorylation Is Regulated by Gq Protein-Dependent but Arrestin-Independent Pathways.
    Title: Histamine H(1) Receptor-Mediated JNK Phosphorylation Is Regulated by G(q) Protein-Dependent but Arrestin-Independent Pathways.
  2. Histamine H1- and H4-receptor expression in human colon-derived cell lines.
    Title: Histamine H(1)- and H(4)-receptor expression in human colon-derived cell lines.
  3. Pharmacological Characterization of the Zebrafish (Danio Rerio) Histamine H1 Receptor Reveals the Involvement of the Second Extracellular Loop in the Binding of Histamine.
    Title: Pharmacological Characterization of the Zebrafish (Danio Rerio) Histamine H(1) Receptor Reveals the Involvement of the Second Extracellular Loop in the Binding of Histamine.
  4. Differential regulation of histamine H1 receptor-mediated ERK phosphorylation by Gq proteins and arrestins.
    Title: Differential regulation of histamine H(1) receptor-mediated ERK phosphorylation by G(q) proteins and arrestins.
  5. Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration.
    Title: Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration.
  6. Molecular Signaling and Transcriptional Regulation of Histamine H1 Receptor Gene.
    Title: Molecular Signaling and Transcriptional Regulation of Histamine H(1) Receptor Gene.
  7. Epigallocatechin gallate stimulated histamine production and downregulated histamine H1 receptor in oral cancer cell lines expressing histidine decarboxylase.
    Title: Epigallocatechin gallate stimulated histamine production and downregulated histamine H1 receptor in oral cancer cell lines expressing histidine decarboxylase.
  8. P2X4 Receptors Mediate Ca(2+) Release from Lysosomes in Response to Stimulation of P2X7 and H1 Histamine Receptors.
    Title: P2X4 Receptors Mediate Ca(2+) Release from Lysosomes in Response to Stimulation of P2X7 and H(1) Histamine Receptors.
  9. Analysis of Missense Variants in the Human Histamine Receptor Family Reveals Increased Constitutive Activity of E410(6.30x30)K Variant in the Histamine H1 Receptor.
    Title: Analysis of Missense Variants in the Human Histamine Receptor Family Reveals Increased Constitutive Activity of E410(6.30×30)K Variant in the Histamine H(1) Receptor.
  10. Histamine receptor 1 is expressed in leukaemic cells and affects differentiation sensitivity.
    Title: Histamine receptor 1 is expressed in leukaemic cells and affects differentiation sensitivity.
Submit: New GeneRIF Correction See all GeneRIFs (84)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histamine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to histamine ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in memory IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic plasticity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
  
involved_in visual learning IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histamine H1 receptor
Names
histamine receptor, subclass H1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000861.3 → NP_000852.1  histamine H1 receptor

    See identical proteins and their annotated locations for NP_000852.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as H/I/K, differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC083855, BC060802, BM905371, D28481, DB073635
    Consensus CDS
    CCDS2604.1
    UniProtKB/Swiss-Prot
    A8K047, P35367, Q6P9E5
    UniProtKB/TrEMBL
    A8K7Z2
    Related
    ENSP00000380247.1, ENST00000397056.1
    Conserved Domains (1) summary
    cd15050
    Location:28 → 479
    7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001098211.2 → NP_001091681.1  histamine H1 receptor

    See identical proteins and their annotated locations for NP_001091681.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as F/K, differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC083855, BM905371, D28481, DA372691, DB073635
    Consensus CDS
    CCDS2604.1
    UniProtKB/Swiss-Prot
    A8K047, P35367, Q6P9E5
    UniProtKB/TrEMBL
    A8K7Z2
    Conserved Domains (1) summary
    cd15050
    Location:28 → 479
    7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_001098212.2 → NP_001091682.1  histamine H1 receptor

    See identical proteins and their annotated locations for NP_001091682.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as B/K, differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC083855, BM905371, BP366267, D28481
    Consensus CDS
    CCDS2604.1
    UniProtKB/Swiss-Prot
    A8K047, P35367, Q6P9E5
    UniProtKB/TrEMBL
    A8K7Z2
    Related
    ENSP00000397028.2, ENST00000431010.3
    Conserved Domains (1) summary
    cd15050
    Location:28 → 479
    7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. NM_001098213.2 → NP_001091683.1  histamine H1 receptor

    See identical proteins and their annotated locations for NP_001091683.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as A/K, represents the longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC083855, BM905371, D28481, DB073635, DC300229
    Consensus CDS
    CCDS2604.1
    UniProtKB/Swiss-Prot
    A8K047, P35367, Q6P9E5
    UniProtKB/TrEMBL
    A8K7Z2
    Related
    ENSP00000406705.2, ENST00000438284.2
    Conserved Domains (1) summary
    cd15050
    Location:28 → 479
    7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    11137238..11263557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    11131678..11258484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35367.1 GenPept UniProtKB/Swiss-Prot:P35367

Gene LinkOut

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