hpxa hemopexin a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hpxaprovided by ZNC
Official Full Name: hemopexin aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5773
See related: Ensembl:ENSDARG00000012609 AllianceGenome:ZFIN:ZDB-GENE-030131-5773
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hpx; hpx a; wu:fi17f11; wu:fi19a10
Summary: Predicted to enable heme transmembrane transporter activity and metal ion binding activity. Acts upstream of or within cellular response to estrogen stimulus. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in blood; liver; and male organism. Orthologous to human HPX (hemopexin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (32840928..32847639, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (33030182..33036893, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi17f11.x1 (e-PCR)
- UniSTS:196936

fi03a09.x1 (e-PCR)
- UniSTS:196601

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heme transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to estrogen stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within heme transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular iron ion homeostasis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hemopexin

NP_001315463.1

EC 3.2.1.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001328534.1 → NP_001315463.1 hemopexin precursor

Status: VALIDATED

Source sequence(s)

BC056563, CT030044

UniProtKB/Swiss-Prot

A9JSW7, Q6PHG2

Related

ENSDARP00000111337.2, ENSDART00000121506.4

Conserved Domains (2) summary

cd00094
Location:49 → 243

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

cl02471
Location:257 → 445

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

32840928..32847639 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001111147.1: Suppressed sequence

Description

NM_001111147.1: This RefSeq was removed because currently there is insufficient support for the transcript.