Med13 mediator complex subunit 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Med13provided by MGI
Official Full Name: mediator complex subunit 13provided by MGI
Primary source: MGI:MGI:3029632
See related: Ensembl:ENSMUSG00000034297 AllianceGenome:MGI:3029632
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Thrap1; Trap240; D030023K18; 1110067M05Rik
Summary: Predicted to enable nuclear thyroid hormone receptor binding activity and transcription coactivator activity. Involved in cholesterol homeostasis; negative regulation of DNA-binding transcription factor activity; and triglyceride homeostasis. Part of mediator complex. Is expressed in several structures, including cerebral cortex; early embryo; gut; hemolymphoid system gland; and reproductive system. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human MED13 (mediator complex subunit 13). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 6.7), whole brain E14.5 (RPKM 6.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 51.75 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (86157859..86248422, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (86267033..86357596, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MED13 and glycolysis are conserved modifiers of alpha-synuclein-associated neurodegeneration.
Title: MED13 and glycolysis are conserved modifiers of α-synuclein-associated neurodegeneration.
Protein tyrosine phosphatase 1B regulates miR-208b-argonaute 2 association and thyroid hormone responsiveness in cardiac hypertrophy.
Title: Protein tyrosine phosphatase 1B regulates miR-208b-argonaute 2 association and thyroid hormone responsiveness in cardiac hypertrophy.
The Mediator complex kinase module is necessary for fructose regulation of liver glycogen levels through induction of glucose-6-phosphatase catalytic subunit (G6pc).
Title: The Mediator complex kinase module is necessary for fructose regulation of liver glycogen levels through induction of glucose-6-phosphatase catalytic subunit (G6pc).
these studies reveal cardiac transcriptional pathways regulated in response to hypothyroidism and re-establishment of a euthyroid state and define molecular pathways that are regulated by Med13 in response to thyroid hormone signaling.
Title: Regulation of cardiac transcription by thyroid hormone and Med13.
Our data demonstrate an essential role for MED13 in supporting chromatin reprogramming and directed transcription of essential genes during zygotic genome activation.
Title: Mediator complex component MED13 regulates zygotic genome activation and is required for postimplantation development in the mouse.
MED13 suppressed the expression of genes involved in glucose uptake and metabolism in skeletal muscle by inhibiting the nuclear receptor NURR1 and the MEF2 transcription factor.
Title: A MED13-dependent skeletal muscle gene program controls systemic glucose homeostasis and hepatic metabolism.
Results delineate a genetic pathway whereby MED13 and miR-208a function in the heart to control whole-body metabolism and unveil a role of the heart in systemic energy homeostasis.
Title: A cardiac microRNA governs systemic energy homeostasis by regulation of MED13.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BI295544 (e-PCR)
- UniSTS:246659

D17S1598 (e-PCR)
- UniSTS:153543

THRAP1__5254 (e-PCR)
- UniSTS:464605

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear thyroid hormone receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear thyroid hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cholesterol homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription initiation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription initiation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of CKM complex	IEA Inferred from Electronic Annotation more info
part_of CKM complex	ISO Inferred from Sequence Orthology more info
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
part_of mediator complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mediator of RNA polymerase II transcription subunit 13

Names: Zmediator complex subunit 13; mediator of RNA polymerase II transcription, subunit 13; thyroid hormone receptor associated protein 1; thyroid hormone receptor associated protein, 240 kDa subunit; thyroid hormone receptor-associated protein complex 240 kDa component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080931.2 → NP_001074400.1 mediator of RNA polymerase II transcription subunit 13

See identical proteins and their annotated locations for NP_001074400.1

Status: VALIDATED

Source sequence(s)

AL592065, AL596256

Consensus CDS

CCDS36267.1

UniProtKB/Swiss-Prot

Q3V3P6, Q5SWW4, Q6ZQ90

Related

ENSMUSP00000044268.9, ENSMUST00000043624.9

Conserved Domains (2) summary

pfam06333
Location:1637 → 2158

Med13_C; Mediator complex subunit 13 C-terminal

pfam11597
Location:14 → 384

Med13_N; Mediator complex subunit 13 N-terminal