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Hs3st6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 [ Mus musculus (house mouse) ]

Gene ID: 328779, updated on 2-Nov-2024

Summary

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Official Symbol
Hs3st6provided by MGI
Official Full Name
heparan sulfate (glucosamine) 3-O-sulfotransferase 6provided by MGI
Primary source
MGI:MGI:3580487
See related
Ensembl:ENSMUSG00000039628 AllianceGenome:MGI:3580487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3-OST-6
Summary
Enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Involved in heparan sulfate proteoglycan biosynthetic process. Acts upstream of or within blastocyst hatching. Predicted to be located in Golgi membrane. Is expressed in alimentary system; early conceptus; integumental system; lung; and nervous system. Human ortholog(s) of this gene implicated in hereditary angioedema. Orthologous to human HS3ST6 (heparan sulfate-glucosamine 3-sulfotransferase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in mammary gland adult (RPKM 10.9), genital fat pad adult (RPKM 9.3) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Hs3st6 in Genome Data Viewer
Location:
17 A3.3; 17 12.53 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24971565..24977664)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24752988..24758690)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E265 Neighboring gene ribosomal protein L3-like Neighboring gene methionine sulfoxide reductase B1 Neighboring gene meiosis specific with OB domains Neighboring gene STARR-positive B cell enhancer ABC_E486 Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene fumarylacetoacetate hydrolase domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of heparan sulphate 3-O-sulphotransferase isoform 6 and its role in assisting the entry of herpes simplex virus type 1. Xu D, et al. Biochem J, 2005 Jan 15. PMID 15303968, Free PMC Article
  2. WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors. Motamedi FJ, et al. Nat Commun, 2014 Jul 17. PMID 25031030
  3. Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function. Patel VN, et al. Matrix Biol, 2021 Sep. PMID 34653670, Free PMC Article
  4. Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Patel VN, et al. Nat Commun, 2024 Aug 31. PMID 39217171, Free PMC Article
  5. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Jones MR, et al. Front Genet, 2018. PMID 30728831, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
heparan sulfate glucosamine 3-O-sulfotransferase 6
Names
heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6
NP_001012402.1
NP_001344269.1
NP_001344271.1
XP_006524490.1
XP_030105708.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012402.2 → NP_001012402.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform 1

    See identical proteins and their annotated locations for NP_001012402.1

    Status: VALIDATED

    Source sequence(s)
    AK146974, AY574375
    Consensus CDS
    CCDS28496.1
    UniProtKB/Swiss-Prot
    Q5GFD5
    UniProtKB/TrEMBL
    A2RTI7, B7ZNT8
    Related
    ENSMUSP00000040919.7, ENSMUST00000044922.8
    Conserved Domains (1) summary
    pfam00685
    Location:91 → 326
    Sulfotransfer_1; Sulfotransferase domain

  2. NM_001357340.1 → NP_001344269.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK146974, AY574375
    UniProtKB/TrEMBL
    Q3UIC7
    Conserved Domains (1) summary
    pfam00685
    Location:30 → 186
    Sulfotransfer_1; Sulfotransferase domain

  3. NM_001357342.1 → NP_001344271.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154566, AY574375
    UniProtKB/TrEMBL
    Q3UIC7
    Conserved Domains (1) summary
    pfam00685
    Location:30 → 186
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24971565..24977664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249848.2 → XP_030105708.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform X1

    Conserved Domains (1) summary
    pfam00685
    Location:51 → 207
    Sulfotransfer_1; Sulfotransferase domain

  2. XM_006524427.5 → XP_006524490.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform X2

    See identical proteins and their annotated locations for XP_006524490.1

    UniProtKB/TrEMBL
    Q3UIC7
    Conserved Domains (1) summary
    pfam00685
    Location:30 → 186
    Sulfotransfer_1; Sulfotransferase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5GFD5.1 GenPept UniProtKB/Swiss-Prot:Q5GFD5

Gene LinkOut

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